ArticleJournal of clinical microbiology2004
Concurrent infections with vector-borne pathogens associated with fatal hemolytic anemia in a cattle herd in Switzerland.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Global Prevalence of Anaplasma phagocytophilum in Cattle: A One Health Perspective, Meta-Analysis and Future Predictions (up to 2035).Veterinary medicine and science · 2025Pooled it
- Investigating Mycoplasma wenyonii and Candidatus Mycoplasma haematobovis coinfection patterns in cattle from southwestern France reveals strain-specific traits.Veterinary research · 2026Article
- From Benign Parasite to Emerging Pathogen: A Review ofAnimals : an open access journal from MDPI · 2026Review
- Hemoglobinuria associated with Candidatus Mycoplasma Haemobos in a primiparous Holstein cow in Turkey: a case report.Veterinary research communications · 2026Article
- Haematology, serum biochemistry, innate and adaptive immune system responses to blood pathogen infections in cattle: A review.Parasitology research · 2026Review
- Integrated Molecular and Hematobiochemical Biomarkers for the Detection of Bovine Babesiosis in Holstein Calves.Veterinary sciences · 2026Article
- First molecular evidence of Bartonella spp. and hemoplasmas in cattle from Mozambique.Tropical animal health and production · 2026Article
- Molecular epidemiology, symptomatic analysis of anaplasmosis and associated study of milk reduction in cattle from district Nowshera, KP, Pakistan.Irish veterinary journal · 2025Article
- First report of Anaplasma marginale in the European bison Bison bonasus.Parasites & vectors · 2025Article
- Effects of host sex, age and behaviour on co-infection patterns in a wild ungulate.Parasitology · 2025Article
- Occurrence of tick-borne haemoparasites in South African rodent species evidence ofInternational journal for parasitology. Parasites and wildlife · 2025Article
- Prevalence of haemotropic mycoplasmas and blood piroplasmids in domestic and wild ruminants in Slovakia, Central Europe.Current research in parasitology & vector-borne diseases · 2025Article
- First molecular evidence of bovine hemoplasmas in houseflies (Musca domestica).BMC veterinary research · 2024Article
- Hemotrophic Mycoplasmas-Vector Transmission in Livestock.Microorganisms · 2024Review
- Comparison of blood profiles between housed and grazing Korean indigenous cattle (Hanwoo).Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2024Article
- Wide bovine tick-borne pathogen spectrum: Predominancy of Theileria annulata and the first molecular detection of Ehrlichia minasensis in Turkey.Veterinary research communications · 2024Article
- Preliminary report of Mycoplasma Wenoynii and Candidatus Mycoplasma haemobos infection in Korean native cattle.BMC veterinary research · 2024Article
- Prevalence of tick-borne bacterial pathogens in Germany-has the situation changed after a decade?Frontiers in cellular and infection microbiology · 2024Article
- Tick-borne Pathogen Detection and Its Association with Alterations in Packed Cell Volume of Dairy Cattle in Thailand.Animals : an open access journal from MDPI · 2023Article
- Surveillance and Risk Analysis for Bovine Babesiosis in England and Wales to Inform Disease Distribution.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine anaplasmosis is a vector-borne disease that results in substantial economic losses in other parts of the world but so far not in northern Europe. In August 2002, a fatal disease outbreak was reported in a large dairy herd in the Swiss canton of Grisons. Diseased animals experienced fever, anorexia, agalactia, and depression. Anemia, ectoparasite infestation, and, occasionally, hemoglobinuria were observed. To determine the roles of vector-borne pathogens and to characterize the disease, blood samples were collected from all 286 animals: 50% of the cows were anemic. Upon microscopic examination of red blood cells, Anaplasma marginale inclusion bodies were found in 47% of the cows. The infection was confirmed serologically and by molecular methods. Interestingly, we also found evidence of infections with Anaplasma phagocytophilum, large Babesia and Theileria spp., and Mycoplasma wenyonii. The last two species had not previously been described in Switzerland. Anemia was significantly associated with the presence of the infectious agents detected, with the exception of A. phagocytophilum. Remarkably, concurrent infections with up to five infectious vector-borne agents were detected in 90% of the ill animals tested by PCR. We concluded that A. marginale was the major cause of the hemolytic anemia, while coinfections with other agents exacerbated the disease. This was the first severe disease outbreak associated with concurrent infections with vector-borne pathogens in alpine Switzerland; it was presumably curtailed by culling of the entire herd. It remains to be seen whether similar disease outbreaks will have to be anticipated in northern Europe in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.