Evidence map›Paper›PMID 15297505›Full record

ArticleJournal of clinical microbiology2004

Comparison of results of fluconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global antifungal surveillance program.

M A Pfaller, K C Hazen, S A Messer, L Boyken, S Tendolkar, R J Hollis, D J Diekema

Abstract readComparative Study
In one paragraph

Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Article
  3. Antifungal Testing of VaginalJournal of fungi (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Antifungal Susceptibility Testing: Current Approaches.Clinical microbiology reviews · 2020
    Review
  7. Article
  8. Article
  9. Nosocomial candidiasis in Rio de Janeiro State: Distribution and fluconazole susceptibility profile.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2015
    Article
  10. The effect of biomaterials and antifungals on biofilm formation by Candida species: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
    Review
  11. Article
  12. Article
  13. Epidemiology of invasive fungal infections in the mediterranean area.Mediterranean journal of hematology and infectious diseases · 2011
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M A PfallerDepartment of Pathology, Roy J. and Lucille A. Carver College of Medicin and College of Public Health, University of Iowa College of Medicine, Iowa City, IA 52242, USA. michael-pfaller@uiowa.edu
K C Hazen
S A Messer
L Boyken
S Tendolkar
R J Hollis
D J Diekema

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The accuracy of antifungal susceptibility tests is important for accurate resistance surveillance and for the clinical management of patients with serious infections. Our main objective was to compare the results of fluconazole disk diffusion testing of Candida spp. performed by ARTEMIS participating centers with disk diffusion and MIC results obtained by the central reference laboratory. A total of 2,949 isolates of Candida spp. were tested by NCCLS disk diffusion and reference broth microdilution methods in the central reference laboratory. These results were compared to the results of disk diffusion testing performed in the 54 participating centers. All tests were performed and interpreted following NCCLS recommendations. Overall categorical agreement between participant disk diffusion test results and reference laboratory MIC results was 87.4%, with 0.2% very major errors (VME) and 3.3% major errors (ME). The categorical agreement between the disk diffusion test results obtained in the reference laboratory with the MIC test results was similar: 92.8%. Likewise, good agreement was observed between participant disk diffusion test results and reference laboratory disk diffusion test results: 90.4%, 0.4% VME, and 3.4% ME. The disk diffusion test was especially reliable in detecting those isolates of Candida spp. that were characterized as resistant by reference MIC testing. External quality assurance data obtained by surveillance programs such as the ARTEMIS Global Antifungal Surveillance Program ensure the generation of useful surveillance data and result in the continued improvement of antifungal susceptibility testing practices.

Indexed as

Antifungal AgentsBase SequenceCandidaDNA PrimersFluconazoleLaboratoriesMicrobial Sensitivity TestsPolymerase Chain ReactionQuality ControlReproducibility of ResultsSpecies SpecificityAntifungal AgentsDNA PrimersFluconazole

Identifiers

PMID15297505
PMCPMC497595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.