ArticleJournal of clinical microbiology2004
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Bartonellosis in World Health Organization Eastern Mediterranean Region, a systematic review and meta-analysis.European journal of public health · 2025Pooled it
- The Global Molecular Prevalence ofTransboundary and emerging diseases · 2023Pooled it
- Flea infestation and molecular detection of Rickettsia and Bartonella spp. in domestic dog-associated fleas from the inter-Andean basin of Cundinamarca, Colombia.Medical and veterinary entomology · 2026Article
- Pathogenic bacterial species and the microbiome of cat fleas (Ctenocephalides felis) inhabiting flea-infested homes.PloS one · 2026Article
- First isolation and genomic insights ofFrontiers in microbiology · 2026Article
- Rabies virus, Bartonella koehlerae and Leishmania infantum coinfection in a black Myotis (Myotis nigricans) from southeastern Brazil.Veterinary research communications · 2025Article
- Diversity and Multiple Infections ofPathogens (Basel, Switzerland) · 2024Article
- Genetic diversity of Bartonella species in small mammals in the Qinghai Menyuan section of Qilian Mountain National Park, China.Scientific reports · 2024Article
- Evaluation of the available animal models forOne health (Amsterdam, Netherlands) · 2024Review
- Vector biology of the cat flea Ctenocephalides felis.Trends in parasitology · 2024Review
- Genetic characterization of Bartonella henselae samples isolated from stray cats by multi-locus sequence typing.BMC veterinary research · 2023Article
- Case series of 12 Bartonella quintana endocarditis from the Southwest Indian Ocean.PLoS neglected tropical diseases · 2023Article
- Viability and Desiccation Resistance ofPathogens (Basel, Switzerland) · 2023Article
- The diverse genetic genotypes of Bartonella species circulating in rodents from Inner Mongolia, Northern China.PLoS neglected tropical diseases · 2023Article
- Article
- Comparison of Biological Activities of BafA Family Autotransporters withinInfection and immunity · 2023Article
- The association of host and vector characteristics withFrontiers in microbiology · 2023Article
- Identification of microbial taxa present in Ctenocephalides felis (cat flea) reveals widespread co-infection and associations with vector phylogeny.Parasites & vectors · 2022Article
- Molecular prevalence and genetic diversity of Bartonella spp. in stray cats of İzmir, Turkey.Parasites & vectors · 2022Article
- Prevalence and diversity of small rodent-associated Bartonella species in Shangdang Basin, China.PLoS neglected tropical diseases · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bartonella koehlerae is reported for the first time to be a human pathogen that causes culture-negative endocarditis. It is also shown that this species, isolated twice before from domestic cats, can be recovered as well from a stray cat population in Israel. This work follows a recent report of the same case in which the causative agent was misidentified as B. henselae, based on serology and PCR-restriction fragment length polymorphism (RFLP) analysis (A. Schattner, O. Zimhony, B. Avidor, and M. Gilad, Lancet 361:1786, 2003). B. koehlerae was identified in the valvular tissue of an endocarditis patient by DNA sequencing of the PCR products of two Bartonella genes: the genes for citrate synthase (gltA) and riboflavin synthase (ribC). The commonly used PCR-RFLP analysis of the TaqI-digested gltA PCR product did not distinguish between B. koehlerae and B. quintana or between B. elizabethae and B. clarridgeiae. PmlI digestion of the gltA amplification product failed to differentiate between B. quintana, B. clarridgeiae, and B. elizabethae. RFLP analysis of the heat shock protein (htrA) gene by TaqI digestion misidentified B. koehlerae as B. henselae. However, RFLP analysis of the ribC PCR product, digested with TaqI, was able to distinguish between the human endocarditis-associated Bartonella species tested, B. henselae, B. quintana, B. elizabethae, and B. koehlerae, as well as between the cat-associated Bartonella species, B. henselae and B. clarridgeiae. Given the expanding number of Bartonella species emerging as human pathogens, it is suggested that PCR-RFLP analysis for the diagnosis of Bartonella infections target several genes and be coupled with DNA sequencing to avoid species identification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.