ArticleCurrent biology : CB2004
Roundabout 2 regulates migration of sensory neurons by signaling in trans.
Article in Current biology : CB, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- SLIT Loss or Sequestration Increases Mammary Alveologenesis and Lactogenesis.microPublication biology · 2024Article
- The SLIT/ROBO Pathway in Liver Fibrosis and Cancer.Biomolecules · 2023Review
- Article
- Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.Developmental cell · 2022Article
- The Slit-binding Ig1 domain is required for multiple axon guidance activities of Drosophila Robo2.Genesis (New York, N.Y. : 2000) · 2021Article
- Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion.eLife · 2021Article
- Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation.Frontiers in cellular neuroscience · 2021Review
- Slit/Robo Signaling Regulates Multiple Stages of the Development of theFrontiers in cell and developmental biology · 2021Article
- sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS.Neural development · 2019Article
- An RNAi Screen Identifies New Genes Required for Normal Morphogenesis of Larval Chordotonal Organs.G3 (Bethesda, Md.) · 2018Article
- Article
- Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.Developmental cell · 2016Article
- In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains.Neural development · 2016Article
- Slit Binding via the Ig1 Domain Is Essential for Midline Repulsion by Drosophila Robo1 but Dispensable for Receptor Expression, Localization, and Regulation in Vivo.G3 (Bethesda, Md.) · 2015Article
- Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.BMC genomics · 2015Article
- Article
- Cleaved Slit directs embryonic muscles.Fly · 2015Article
- Article
- Slits affect the timely migration of neural crest cells via Robo receptor.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Roundabout is required in the visceral mesoderm for proper microvillus length in the hindgut epithelium.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRoundabout (Robo) receptors and their ligand Slit are important regulators of axon guidance and cell migration. The development of Drosophila embryonic sense organs provides a neuronal migration paradigm where the in vivo roles of Slit and Robo can be assayed using genetics.
resultsHere we show that Slit-Robo signaling controls migration of Drosophila larval sensory neurons that are part of the Chordotonal (Cho) stretch receptor organs. We used live imaging to show that abdominal Cho organs normally migrate ventrally during development, whereas thoracic Cho organs do not. Robo2 overexpression in cis (in the sensory neurons) or in trans (on neighboring visceral mesoderm) transforms abdominal organs to a thoracic morphology and position by blocking migration, while loss of Slit-Robo signaling produces a reverse transformation in which thoracic organs migrate ectopically. Rescue and tissue-specific knockout experiments indicate that trans signaling by Robo2 contributes to the normal positioning of the thoracic Cho organs. The differential positioning of Cho organs between the thorax and abdomen is known to be regulated by Hox genes, and we show that the essential Hox cofactor Homothorax, represses Robo2 expression in the abdominal visceral mesoderm.
conclusionsOur results suggest that segment-specific neuronal migration patterns are directed through a novel signaling complex (the "Slit sandwich") in which Robo2 on the thoracic visceral mesoderm binds to Slit and presents it to Robo receptors on Cho neurons. The differential positioning of Cho organs between thorax and abdomen may be determined by Hox gene-mediated repression of robo2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.