ReviewCurrent atherosclerosis reports2004
Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk.
Review in Current atherosclerosis reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.American journal of human genetics · 2008Pooled it
- Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial.The Journal of nutrition · 2015Trial
- Phenolic compounds naturally present in olive oil and lowering of blood LDL-cholesterol and systolic blood pressure, therefore reducing the risk of coronary heart disease: Evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.EFSA journal. European Food Safety Authority · 2025Article
- Circumventing Cardiovascular Calamities: The Dawn of ANGPTL3 Blockade in Severe Dyslipidemia Management.Cardiovascular & hematological disorders drug targets · 2024Review
- Nonlinear relationship between serum 25-hydroxyvitamin D and lipid profile in Chinese adults.Frontiers in nutrition · 2024Article
- Flow-Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes.Journal of the American Heart Association · 2022Article
- Nonadditive expression of lipid metabolism pathway-related genes in intestine of hybrids of Nile tilapia females (Oreochromis niloticus) and blue tilapia males (Oreochromis aureus).Molecular biology reports · 2019Article
- Article
- Traditional Chinese medicine for lipid metabolism disorders.American journal of translational research · 2017Review
- Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise.PloS one · 2017Article
- Fasting Lipoprotein Lipase Protein Levels Can Predict a Postmeal Increment of Triglyceride Levels in Fasting Normohypertriglyceridemic Subjects.Journal of clinical laboratory analysis · 2016Article
- Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways.Journal of lipid research · 2016Article
- Complexity of microRNA function and the role of isomiRs in lipid homeostasis.Journal of lipid research · 2013Review
- Effects of oxidation on structural stability and remodeling of human very low density lipoprotein.Biochemistry · 2010Article
- The vascular contribution to Alzheimer's disease.Clinical science (London, England : 1979) · 2010Review
- Mechanisms of lipase maturation.Clinical lipidology · 2010Article
- Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance.The Journal of biological chemistry · 2010Article
- A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.The Journal of biological chemistry · 2009Article
- Increased postprandial triglyceride-rich lipoprotein levels in elderly survivors of myocardial infarction.Lipids · 2008Article
- Delayed metabolism of postprandial triglyceride-rich lipoproteins in subjects with echolucent carotid plaques.Lipids · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For over 50 years, biologists and clinicians have studied lipoprotein lipase (LPL) and learned about its structure, function, cellular production, physiology, and human genetics. LPL is the principal enzyme that removes triglyceride from the bloodstream. It also determines plasma levels of high-density lipoprotein. Surprisingly, within the past several years, a number of new and unexpected proteins have been discovered that regulate the actions of LPL. These include the very low-density lipoprotein receptor, angiopoetin-like protein 3, and apolipoprotein A-V. In addition, mouse genetic studies have confirmed tissue culture findings of nonenzymatic roles of LPL both in lipid metabolism and atherogenesis. These basic observations are now being related to new information on human genetic polymorphism in this gene that is likely to affect clinical evaluation of lipoprotein disorders and cardiac risk.
Indexed as
Identifiers
15296698What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.