ArticleBMC psychiatry2004
Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.
Article in BMC psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Glutamatergic abnormalities of the thalamus in schizophrenia: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2008Pooled it
- Cognitive Skills and DNA Methylation Are Correlating in Healthy and Novice College Students Practicing Preksha Dhyāna Meditation.Brain sciences · 2023Article
- The Role of Glutamatergic Gene Polymorphisms in the Clinical Phenotypes of Schizophrenia.Genes · 2023Article
- Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population.BMC psychiatry · 2022Article
- Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population.Neuropsychiatric disease and treatment · 2019Article
- Genome-Wide Association Study of Psychosis Proneness in the Finnish Population.Schizophrenia bulletin · 2017Article
- Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine.Molecular neuropsychiatry · 2017Article
- Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia.Translational psychiatry · 2015Article
- Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity.Neurochemical research · 2015Review
- Article
- Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.Pharmacogenetics and genomics · 2013Article
- GABA and Glutamate Transporters in Brain.Frontiers in endocrinology · 2013Review
- Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.Molecular psychiatry · 2012Article
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2011Article
- Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms.Behavioral and brain functions : BBF · 2011Article
- The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia.BMC psychiatry · 2008Article
- Shared gene expression alterations in schizophrenia and bipolar disorder.Biological psychiatry · 2008Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe glutamatergic dysfunction hypothesis of schizophrenia suggests that genes involved in glutametergic transmission are candidates for schizophrenic susceptibility genes. We have been performing systematic association studies of schizophrenia with the glutamate receptor and transporter genes. In this study we report an association study of the excitatory amino acid transporter 2 gene, SLC1A2 with schizophrenia.
methodsWe genotyped 100 Japanese schizophrenics and 100 controls recruited from the Kyushu area for 11 single nucleotide polymorphism (SNP) markers distributed in the SLC1A2 region using the direct sequencing and pyrosequencing methods, and examined allele, genotype and haplotype association with schizophrenia. The positive finding observed in the Kyushu samples was re-examined using 100 Japanese schizophrenics and 100 controls recruited from the Aichi area.
resultsWe found significant differences in genotype and allele frequencies of SNP2 between cases and controls (P = 0.013 and 0.008, respectively). After Bonferroni corrections, the two significant differences disappeared. We tested haplotype associations for all possible combinations of SNP pairs. SNP2 showed significant haplotype associations with the disease (P = 9.4 x 10-5, P = 0.0052 with Bonferroni correction, at the lowest) in 8 combinations. Moreover, the significant haplotype association of SNP2-SNP7 was replicated in the cumulative analysis of our two sample sets.
conclusionWe concluded that at least one susceptibility locus for schizophrenia is probably located within or nearby SLC1A2 in the Japanese population.
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