ArticleMalaria journal2004
In vivo transcriptional profiling of Plasmodium falciparum.
Article in Malaria journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Genome-wide analysis of strand-specific transcription and DNA methylation inFrontiers in microbiology · 2026Article
- Determination of the Stage Composition ofmSystems · 2022Article
- Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies.EBioMedicine · 2019Article
- The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background.Nature communications · 2018Article
- Systems Biology-Based Investigation of Host-Plasmodium Interactions.Trends in parasitology · 2018Review
- Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Adaptation of Plasmodium falciparum to its transmission environment.Nature ecology & evolution · 2018Article
- Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers.PloS one · 2014Article
- Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response.Malaria journal · 2013Article
- Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria.Malaria journal · 2012Article
- Module-based subnetwork alignments reveal novel transcriptional regulators in malaria parasite Plasmodium falciparum.BMC systems biology · 2012Article
- A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii.Cellular microbiology · 2011Article
- Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family.Malaria journal · 2011Article
- Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates.PLoS pathogens · 2009Article
- Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?PloS one · 2009Article
- New insights into the genetic regulation of Plasmodium falciparum obtained by Bayesian modeling.Gene regulation and systems biology · 2007Article
- Molecular epidemiology of malaria.Clinical microbiology reviews · 2007Review
- Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?Malaria journal · 2006Review
- In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins.The Journal of infectious diseases · 2005Article
- Transcriptome analysis of antigenic variation in Plasmodium falciparum--var silencing is not dependent on antisense RNA.Genome biology · 2005Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth host and pathogen factors contribute to disease outcome in Plasmodium falciparum infection. The feasibility of studying the P. falciparum in vivo transcriptome to understand parasite transcriptional response while it resides in the human host is presented.
methodsA custom made oligonucleotide array with probes based on the P. falciparum 3D7 laboratory strain chromosome 2 sequence was used to detect in vivo P. falciparum transcripts. This study analyzed transcripts from total RNA derived from small blood samples of P. falciparum infected patients and compared the in vivo expression profile to the in vitro cultivated 3D7 strain transcriptome.
resultsThe data demonstrated that in vivo transcription can be studied from a small blood sample, despite the abundance of human RNA. The in vivo transcriptome is similar to the 3D7 ring stage transcriptome, but there are significant differences in genes encoding a sexual stage antigen and surface proteins.
conclusionsWhole genome transcription analysis of P. falciparum can be carried out successfully and further studies in selected patient cohorts may provide insight into parasite in vivo biology and defense against host immunity.
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