Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Adenosine sestamibi SPECT post-infarction evaluation (INSPIRE) trial: A randomized, prospective multicenter trial evaluating the role of adenosine Tc-99m sestamibi SPECT for assessing risk and therapeutic outcomes in survivors of acute myocardial infarction.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01518777 (Reducing Radioisotope Dose in Regadenoson SPECT Myocardial Perfusion Imaging), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Radioisotope Dose in Regadenoson SPECT Myocardial Perfusion Imaging: Comparison of Half-Dose Scans Using a Novel Solid-State-Detector Dedicated Cardiac Camera to Full Dose Scans Acquired On Standard Equipment
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Assessment of acute myocardial infarction: current status and recommendations from the North American society for Cardiovascular Imaging and the European Society of Cardiac Radiology.The international journal of cardiovascular imaging · 2011Guideline
- Stress protocols and tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2006Guideline
- Gated myocardial perfusion single photon emission computed tomography in the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial, Veterans Administration Cooperative study no. 424.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2006Trial
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Refining risk in diabetes and CAD with SPECT MPI: New insights and future challenges.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Value of gated-SPECT MPI for ischemia-guided PCI of non-culprit vessels in STEMI patients with multivessel disease after primary PCI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Cardiological Society of India: Position statement for the management of ST elevation myocardial infarction in India.Indian heart journal · 2017Review
- Serious and potentially life threatening complications of cardiac stress testing: Physiological mechanisms and management strategies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Lessons learned from MPI and physiologic testing in randomized trials of stable ischemic heart disease: COURAGE, BARI 2D, FAME, and ISCHEMIA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- Assessing risk in acute chest pain: The value of stress myocardial perfusion imaging in patients admitted through the emergency department.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction.Heart (British Cardiac Society) · 2007Article
- Noninvasive monitoring of medical therapy.Current cardiology reports · 2006Review
- Monitoring effectiveness of medical therapy in 2006.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Myocardial metabolic imaging in the acute care setting.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Risk stratification after acute myocardial infarction: is it time to reassess? Implications from the INSPIRE trial.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Assessing progression or regression of CAD: the role of perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreliminary studies indicate that adenosine myocardial perfusion single photon tomography (SPECT) can safely and accurately stratify patients into low and high risk groups early after acute myocardial infarction (AMI). METHODS AND
resultsINSPIRE is a prospective, randomized multicenter trial which enrolled 728 clinically stable survivors of AMI. Following baseline adenosine sestamibi gated SPECT, patients were classified as low, intermediate or high risk based on the quantified total and ischemic left ventricular (LV) perfusion defect size (PDS). A subset of high risk patients with a LV ejection fraction > or =35% were randomized to a strategy of either intensive medical therapy or coronary revascularization. Adenosine SPECT was repeated at 6-8 weeks to determine the relative effects of anti-ischemic therapies on total and ischemic PDS (primary endpoint). All patients were followed for one year. The baseline demographic, clinical and scintigraphic characteristics of the study population are presented. Adenosine SPECT was performed within 1 day of admission in 12% of patients and in 64% by Day 4.
conclusionThe unique study design features of INSPIRE will further clarify the role of adenosine sestamibi SPECT in defining initial patient risk after AMI and in monitoring the benefits of intensive anti-ischemic therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.