ArticleNucleic acids research2004
Complex cis-elements determine an RNA editing site in pea mitochondria.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 75 citations in OpenAlex.
- U-to-C RNA editing by synthetic PPR-DYW proteins in bacteria and human culture cells.Communications biology · 2022Article
- Full Length Transcriptome Highlights the Coordination of Plastid Transcript Processing.International journal of molecular sciences · 2021Article
- RNA Editing and Its Roles in Plant Organelles.Frontiers in genetics · 2021Review
- Systematic analysis reveals cis and trans determinants affecting C-to-U RNA editing in Arabidopsis thaliana.BMC genetics · 2020Article
- One C-to-U RNA Editing Site and Two Independently Evolved Editing Factors: Testing Reciprocal Complementation with DYW-Type PPR Proteins from the MossThe Plant cell · 2020Article
- The chloroplast and mitochondrial C-to-U RNA editing inPlant direct · 2019Article
- Genome-Wide Analysis of Multiple Organellar RNA Editing Factor Family in Poplar Reveals Evolution and Roles in Drought Stress.International journal of molecular sciences · 2019Article
- Molecular and Functional Diversity of RNA Editing in Plant Mitochondria.Molecular biotechnology · 2018Review
- Functional divergence and origin of the DAG-like gene family in plants.Scientific reports · 2017Article
- Identification of two pentatricopeptide repeat genes required for RNA editing and zinc binding by C-terminal cytidine deaminase-like domains.The Journal of biological chemistry · 2013Article
- Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing.PLoS genetics · 2013Article
- Article
- Deletions in cox2 mRNA result in loss of splicing and RNA editing and gain of novel RNA editing sites.PloS one · 2013Article
- A pentatricopeptide repeat protein acts as a site-specificity factor at multiple RNA editing sites with unrelated cis-acting elements in plastids.Nucleic acids research · 2012Article
- The RNA editing pattern of cox2 mRNA is affected by point mutations in plant mitochondria.PloS one · 2011Article
- Editing site analysis in a gymnosperm mitochondrial genome reveals similarities with angiosperm mitochondrial genomes.Current genetics · 2010Article
- Testing for selection on synonymous sites in plant mitochondrial DNA: the role of codon bias and RNA editing.Journal of molecular evolution · 2010Article
- A study of new Arabidopsis chloroplast RNA editing mutants reveals general features of editing factors and their target sites.The Plant cell · 2009Article
- Pentatricopeptide repeat proteins with the DYW motif have distinct molecular functions in RNA editing and RNA cleavage in Arabidopsis chloroplasts.The Plant cell · 2009Article
- Amino acid sequence variations in Nicotiana CRR4 orthologs determine the species-specific efficiency of RNA editing in plastids.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cis-requirements for the first editing site in the atp9 mRNA from pea mitochondria were investigated in an in vitro RNA editing system. Template RNAs deleted 5' of -20 are edited correctly, but with decreased efficiency. Deletions between -20 and the edited nucleotide abolish editing activity. Substitution of the sequences 3' of the editing site has little effect, which suggests that the major determinants reside upstream. Stepwise mutated RNA sequences were used as templates or competitors that divide the cis-elements into several distinct regions. In the template RNAs, mutation of the sequence between -40 and -35 reduces the editing activity, while the region from -15 to -5 is essential for the editing reaction. In competition experiments the upstream region can be titrated, while the essential sequence near the editing site is largely resistant to excess competitor. This observation suggests that either one trans-factor attaches to these separate cis-regions with different affinities or two distinct trans-factors bind to these sequences, and one of which is present in limited amounts, whereas the other one is more abundant in the lysate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.