Evidence map›Paper›PMID 15294856›Full record

Trial reportBMJ (Clinical research ed.)2004

Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery.

Herbert Kiss, Ljubomir Petricevic, Peter Husslein

Registry-linked trialOpen access · bronzeAbstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02979288 (Treatment of the Intermediate Vaginal Microbiota With Vaginal Probiotics Containing Lactobacillus Casei Rhamnosus), which is not on this map. Cited by 63 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 12 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02979288 phase3completednot on this mapstarted 2017, after this paper: background citation

Treatment of the Intermediate Vaginal Microbiota With Vaginal Probiotics Containing Lactobacillus Casei Rhamnosus (Lcr Regenerans) to Improve Pregnancy Outcomes

TypeinterventionalSponsorMedical University of ViennaRan2017 to 2020Enrolled120ConditionsLactobacillus InfectionArmsLactobacillus casei rhamnosus (Lcr 35 regenerans), NO Intervention
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 12 syntheses or guidelines pooled it, 310 citations in OpenAlex.

  1. Pooled it
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  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Antibiotics for treating bacterial vaginosis in pregnancy.The Cochrane database of systematic reviews · 2013
    Pooled it
  8. Cyclo-oxygenase (COX) inhibitors for preventing preterm labour.The Cochrane database of systematic reviews · 2012
    Pooled it
  9. Relaxation therapy for preventing and treating preterm labour.The Cochrane database of systematic reviews · 2012
    Pooled it
  10. Pooled it
  11. Probiotics for preventing preterm labour.The Cochrane database of systematic reviews · 2007
    Pooled it
  12. Antibiotics for treating bacterial vaginosis in pregnancy.The Cochrane database of systematic reviews · 2007
    Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Herbert KissDepartment of Obstetrics and Gynaecology, University of Vienna Medical School, Währinger Gürtel 18-20, A-1090 Vienna, Austria. herbert.kiss@akh-wien.ac.at
Ljubomir Petricevic
Peter Husslein
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether a screening strategy in pregnancy lowers the rate of preterm delivery in a general population of pregnant women.

designMulticentre, prospective, randomised controlled trial.

settingNon-hospital based antenatal clinics.

participants4429 pregnant women presenting for their routine prenatal visits early in the second trimester were screened by Gram stain for asymptomatic vaginal infection. In the intervention group, the women's obstetricians received the test results and women received standard treatment and follow up for any detected infection. In the control group, the results of the vaginal smears were not revealed to the caregivers.

main outcome measuresThe primary outcome variable was preterm delivery at less than 37 weeks. Secondary outcome variables were preterm delivery at less than 37 weeks combined with different birth weight categories equal to or below 2500 g and the rate of late miscarriage.

resultsOutcome data were available for 2058 women in the intervention group and 2097 women in the control group. In the intervention group, the number of preterm births was significantly lower than in the control group (3.0% v 5.3%, 95% confidence interval 1.2 to 3.6; P = 0.0001). Preterm births were also significantly reduced in lower weight categories at less than 37 weeks and <or= 2500 g. Eight late miscarriages occurred in the intervention group and 15 in the control group.

conclusionIntegrating a simple infection screening programme into routine antenatal care leads to a significant reduction in preterm births and reduces the rate of late miscarriage in a general population of pregnant women.

Indexed as

AdultFemaleFollow-Up StudiesHumansMass ScreeningObstetric Labor, PrematurePregnancyPregnancy Complications, InfectiousPregnancy OutcomePrenatal DiagnosisProspective StudiesVaginosis, Bacterial

Identifiers

PMID15294856
PMCPMC509340
OpenAlexW2078797436

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.