ArticleApplied and environmental microbiology2004
Genetic instability of heterozygous, hybrid, natural wine yeasts.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Biocontainment efficacy redefined.Applied and environmental microbiology · 2025Article
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- Genetic improvement of non-conventionalFrontiers in microbiology · 2022Article
- Vinification withoutMicroorganisms · 2020Article
- Genetic Improvement ofMicroorganisms · 2020Article
- Article
- Genetic Polymorphism in Wine Yeasts: Mechanisms and Methods for Its Detection.Frontiers in microbiology · 2017Review
- A new wine Torulaspora delbrueckii killer strain with broad antifungal activity and its toxin-encoding double-stranded RNA virus.Frontiers in microbiology · 2015Article
- Effects of new Torulaspora delbrueckii killer yeasts on the must fermentation kinetics and aroma compounds of white table wine.Frontiers in microbiology · 2015Article
- Characterization, ecological distribution, and population dynamics of Saccharomyces sensu stricto killer yeasts in the spontaneous grape must fermentations of southwestern Spain.Applied and environmental microbiology · 2012Article
- A new wine Saccharomyces cerevisiae killer toxin (Klus), encoded by a double-stranded rna virus, with broad antifungal activity is evolutionarily related to a chromosomal host gene.Applied and environmental microbiology · 2011Article
- Construction of sterile ime1Delta-transgenic Saccharomyces cerevisiae wine yeasts unable to disseminate in nature.Applied and environmental microbiology · 2008Article
- Genetic and physiological alterations occurring in a yeast population continuously propagated at increasing temperatures with cell recycling.World journal of microbiology & biotechnology · 2007Article
- Analysis of homothallic Saccharomyces cerevisiae strain mating during must fermentation.Applied and environmental microbiology · 2007Article
- Microarray karyotyping of commercial wine yeast strains reveals shared, as well as unique, genomic signatures.BMC genomics · 2005Article
- Current awareness on yeast.Yeast (Chichester, England) · 2005Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a genetic instability found in natural wine yeasts but not in the common laboratory strains of Saccharomyces cerevisiae. Spontaneous cyh2(R)/cyh2(R) mutants resistant to high levels of cycloheximide can be directly isolated from cyh2(S)/cyh2(S) wine yeasts. Heterozygous cyh2(R)/cyh2(S) hybrid clones vary in genetic instability as measured by loss of heterozygosity at cyh2. There were two main classes of hybrids. The lawn hybrids have high genetic instability and generally become cyh2(R)/cyh2(R) homozygotes and lose the killer phenotype under nonselective conditions. The papilla hybrids have a much lower rate of loss of heterozygosity and maintain the killer phenotype. The genetic instability in lawn hybrids is 3 to 5 orders of magnitude greater than the highest loss-of-heterozygosity rates previously reported. Molecular mechanisms such as DNA repair by break-induced replication might account for the asymmetrical loss of heterozygosity. This loss-of-heterozygosity phenomenon could be economically important if it causes sudden phenotype changes in industrial or pathogenic yeasts and of more basic importance to the degree that it influences the evolution of naturally occurring yeast populations.
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