ArticleThe Biochemical journal2005
Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane.
Article in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- Structural basis for substrate binding, catalysis, and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor.Structure (London, England : 1993) · 2025Article
- Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression.Cell reports · 2024Article
- Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.Circulation research · 2022Observational
- Creatine Supplementation for Patients with Inflammatory Bowel Diseases: A Scientific Rationale for a Clinical TrialNutrients · 2021Review
- Review
- Mitochondrial Creatine Kinase is Decreased in the Serum of Idiopathic Parkinson's Disease Patients.Aging and disease · 2019Article
- Proteolipid domains form in biomimetic and cardiac mitochondrial vesicles and are regulated by cardiolipin concentration but not monolyso-cardiolipin.The Journal of biological chemistry · 2018Article
- Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.Cardiovascular research · 2018Article
- Cardiolipin in Central Nervous System Physiology and Pathology.Cellular and molecular neurobiology · 2017Review
- The role of succinate and ROS in reperfusion injury - A critical appraisal.Journal of molecular and cellular cardiology · 2017Review
- The role of hexokinase in cardioprotection - mechanism and potential for translation.British journal of pharmacology · 2015Review
- CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex.Journal of cell science · 2014Article
- Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.American journal of physiology. Heart and circulatory physiology · 2013Article
- Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?Frontiers in physiology · 2013Article
- Yeast mitochondrial interactosome model: metabolon membrane proteins complex involved in the channeling of ADP/ATP.International journal of molecular sciences · 2012Review
- The creatine kinase system and pleiotropic effects of creatine.Amino acids · 2011Review
- Flow of energy in the outer retina in darkness and in light.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Mitochondrial therapy for Parkinson's disease: neuroprotective pharmaconutrition may be disease-modifying.Clinical pharmacology : advances and applications · 2010Article
- Article
- Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia.Journal of bioenergetics and biomembranes · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
We have investigated the role of the protein ubiquitous mitochondrial creatine kinase (uMtCK) in the formation and stabilization of inner and outer membrane contact sites. Using liver mitochondria isolated from transgenic mice, which, unlike control animals, express uMtCK in the liver, we found that the enzyme was associated with the mitochondrial membranes and, in addition, was located in membrane-coated matrix inclusions. In mitochondria isolated from uMtCK transgenic mice, the number of contact sites increased 3-fold compared with that observed in control mitochondria. Furthermore, uMtCK-containing mitochondria were more resistant to detergent-induced lysis than wild-type mitochondria. We conclude that octameric uMtCK induces the formation of mitochondrial contact sites, leading to membrane cross-linking and to an increased stability of the mitochondrial membrane architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.