ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
The scarless heart and the MRL mouse.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 59 citations in OpenAlex.
- Characterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains.ImmunoHorizons · 2025Article
- Intersection of Immunity, Metabolism, and Muscle Regeneration in an Autoimmune-Prone MRL Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The superior healing capacity of MRL tendons is minimally influenced by the systemic environment of the MRL mouse.Scientific reports · 2023Article
- Ectopic adipogenesis in response to injury and material implantation in an autoimmune mouse model.bioRxiv : the preprint server for biology · 2023Article
- Markers of Accelerated Skeletal Muscle Regenerative Response in Murphy Roths Large Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors.Stem cells (Dayton, Ohio) · 2019Article
- Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis.International journal of molecular sciences · 2017Review
- Enhanced cartilage repair in 'healer' mice-New leads in the search for better clinical options for cartilage repair.Seminars in cell & developmental biology · 2017Review
- Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment.The Journal of endocrinology · 2016Review
- Inhibition of Wnt/β-catenin pathway promotes regenerative repair of cutaneous and cartilage injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse.BMC genomics · 2015Article
- From Immunity and Vaccines to Mammalian Regeneration.The Journal of infectious diseases · 2015Article
- Allogeneic Bone Marrow Transplant from MRL/MpJ Super-Healer Mice Does Not Improve Articular Cartilage Repair in the C57Bl/6 Strain.PloS one · 2015Article
- Regeneration of articular cartilage in healer and non-healer mice.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Retinal pigment epithelium development, plasticity, and tissue homeostasis.Experimental eye research · 2014Review
- New insights into the morphogenic role of stromal cells and their relevance for regenerative medicine. lessons from the heart.Journal of cellular and molecular medicine · 2014Review
- Increased AMP-activated protein kinase in skeletal muscles of Murphy Roth Large mice and its potential role in altered metabolism.Physiological reports · 2014Article
- Musculoskeletal regeneration and its implications for the treatment of tendinopathy.International journal of experimental pathology · 2013Review
- Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice.Neuropharmacology · 2013Article
- Article
- The superhealing MRL background improves muscular dystrophy.Skeletal muscle · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to regenerate tissues and limbs in its most robust form is seen in many non-mammalian species. The serendipitous discovery that the MRL mouse has a profound capacity for regeneration in some ways rivalling the classic newt and axolotl species raises the possibility that humans, too, may have an innate regenerative ability. The adult MRL mouse regrows cartilage, skin, hair follicles and myocardium with near perfect fidelity and without scarring. This is seen in the ability to close through-and-through ear holes, which are generally used for lifelong identification of mice, and the anatomic and functional recovery of myocardium after a severe cryo-injury. We present histological, biochemical and genetic data indicating that the enhanced breakdown of scar-like tissue may be an underlying factor in the MRL regenerative response. Studies as to the source of the cells in the regenerating MRL tissue are discussed. Such studies appear to support multiple mechanisms for cell replacement.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.