ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
Fibroblast growth factors in epithelial repair and cytoprotection.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 88 citations in OpenAlex.
- Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) inPeerJ · 2025Review
- 3D sheep rumen epithelial structures driven from single cells in vitro.Veterinary research · 2023Article
- Therapeutic role of growth factors in treating diabetic wound.World journal of diabetes · 2023Review
- Prospective use of amniotic mesenchymal stem cell metabolite products for tissue regeneration.Journal of biological engineering · 2023Review
- FGF10 mediates protective anti-oxidative effects in particulate matter-induced lung injury through Nrf2 and NF-κB signaling.Annals of translational medicine · 2022Article
- How plants solubilise seed fats: revisiting oleosin structure and function to inform commercial applications.Biophysical reviews · 2022Review
- Review
- Review
- The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy.Journal of inflammation research · 2021Review
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- Mimicking growth factors: role of small molecule scaffold additives in promoting tissue regeneration and repair.RSC advances · 2019Review
- Emerging Roles of Fibroblast Growth Factor 10 in Cancer.Frontiers in genetics · 2018Article
- Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice.International journal of molecular sciences · 2017Article
- Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis.Translational oncology · 2017Article
- Growth and stress response mechanisms underlying post-feeding regenerative organ growth in the Burmese python.BMC genomics · 2017Article
- Pathophysiological Mechanisms in Sclerosing Skin Diseases.Frontiers in medicine · 2017Review
- Growth factors and IL-17 in hereditary angioedema.Clinical and experimental medicine · 2016Article
- Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.Cell reports · 2014Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth factors are polypeptides that stimulate the division of certain cell types at low concentrations. Fibroblast growth factor (FGF) 7 (FGF-7) and its homologue FGF-10 act specifically on various types of epithelial cells including keratinocytes of the skin, intestinal epithelial cells and hepatocytes. In addition, FGF-7 and FGF-10 have been shown to be more than growth factors: they can protect epithelial cells from damaging effects induced, for example, by radiation and oxidative stress. Therefore, they are currently in clinical trials for the treatment of oral mucositis, a severe side-effect of cancer therapy characterized by painful inflammation and ulceration of the oral epithelium. To gain insight into the mechanisms of FGF-7/FGF-10 action in epithelial cells, we searched for genes that are regulated by these growth factors. Indeed, we identified genes that help us to explain the mechanisms that underlie the effects of FGF-7. Most interestingly, several genes were identified that are likely to mediate the cytoprotective effect of FGF-7 for epithelial cells in vitro and possibly also in injured and diseased tissues in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.