ArticleClinical rheumatology2004
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients.
Article in Clinical rheumatology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983 477 individuals.Human molecular genetics · 2026Pooled it
- Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.Annals of the rheumatic diseases · 2013Pooled it
- Candidate gene studies of fibromyalgia: a systematic review and meta-analysis.Rheumatology international · 2012Pooled it
- [Etiology and pathophysiology of fibromyalgia syndrome and chronic widespread pain].Schmerz (Berlin, Germany) · 2008Guideline
- Influence of Polymorphisms in the HTR3A and HTR3B Genes on Experimental Pain and the Effect of the 5-HT3 Antagonist Granisetron.PloS one · 2016Trial
- A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia.Biomedicines · 2023Review
- New insights into the genetics of fibromyalgia.The Korean journal of internal medicine · 2017Review
- A comparison of the effectiveness of amitriptilin and pregabalin treatment in fibromyalgia patients.Northern clinics of Istanbul · 2017Article
- Fibromyalgia: A Critical and Comprehensive Review.Clinical reviews in allergy & immunology · 2015Review
- Exploring Genetic Susceptibility to Fibromyalgia.Chonnam medical journal · 2015Review
- Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia.Nursing research and practice · 2013Article
- Brain imaging in fibromyalgia.Current pain and headache reports · 2012Review
- Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.Pain research and treatment · 2012Article
- Risk factors predicting the development of widespread pain from chronic back or neck pain.The journal of pain · 2010Article
- Article
- Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality.Rheumatology (Oxford, England) · 2009Article
- Genetic contributions to pain: a review of findings in humans.Oral diseases · 2008Review
- 3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.Trends in pharmacological sciences · 2008Review
- Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.Rheumatology international · 2008Article
- Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats.BMC medical genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in numerous human disorders. Dysfunction of serotonergic neurotransmission is thought to play a major role in the pathophysiology of the fibromyalgia syndrome (FMS) which is characterised by non-restorative sleep and severe pain. In our study, both serotonin receptor subunit genes, HTR3A and HTR3B, have been investigated for sequence variations in FMS patients in order to reveal a possible involvement in the aetiology of FMS. We examined DNA samples from 48 patients with FMS representing sporadic cases by single-strand conformation polymorphism (SSCP) and denaturing high-performance liquid chromatography (dHPLC) analysis, sequenced samples with conspicuous patterns and performed statistical calculations. HTR3A mutational analysis revealed one novel as well as five known sequence variations. Investigating HTR3B, we detected seven formerly described mutations and one novel sequence variant. Statistical computation rated all variants as probably non-disease-related polymorphisms. Nevertheless, one might speculate about an effect of the respective sequence variants on the severity of the disease. Sequence variants of the serotonin receptor subunit genes HTR3A and HTR3B indicate no obvious significance in the aetiology of fibromyalgia, yet they represent the basis for future studies on their pharmacogenetic relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.