ArticleBritish journal of cancer2004
Correlation of in vitro infiltration with glioma histological type in organotypic brain slices.
Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review.F1000Research · 2025Pooled it
- Transferrin-Functionalized Conjugated Polymer Nanoparticles for Enhanced Photodynamic Therapy of Glioblastoma.International journal of nanomedicine · 2026Article
- 5T chemical exchange saturation transfer imaging improves glioma grading and genotyping prediction: a supplement to 3T diffusion and perfusion MRI.Journal of translational medicine · 2025Article
- The Concept of «Peritumoral Zone» in Diffuse Low-Grade Gliomas: Oncological and Functional Implications for a Connectome-Guided Therapeutic Attitude.Brain sciences · 2022Review
- Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients.Neuro-oncology · 2020Article
- Comprehensive analysis of genes based on chr1p/19q co-deletion reveals a robust 4-gene prognostic signature for lower grade glioma.Cancer management and research · 2019Article
- MR Fingerprinting of Adult Brain Tumors: Initial Experience.AJNR. American journal of neuroradiology · 2017Article
- Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness.Journal of experimental & clinical cancer research : CR · 2017Article
- On-Chip Clonal Analysis of Glioma-Stem-Cell Motility and Therapy Resistance.Nano letters · 2016Article
- Establishment and Characterization of a Tumor Stem Cell-Based Glioblastoma Invasion Model.PloS one · 2016Article
- Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells.Tissue engineering. Part B, Reviews · 2014Review
- Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma.Neuro-oncology · 2013Article
- Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.AJNR. American journal of neuroradiology · 2013Article
- Invasion of primary glioma- and cell line-derived spheroids implanted into corticostriatal slice cultures.International journal of clinical and experimental pathology · 2013Article
- Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy.Aging cell · 2012Article
- Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.Cancer research · 2012Article
- Effects of chemotherapeutics on organotypic corticostriatal slice cultures identified by a panel of fluorescent and immunohistochemical markers.Neurotoxicity research · 2012Article
- MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas.Neuro-oncology · 2011Article
- Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.Neoplasia (New York, N.Y.) · 2011Article
- Imaging features of invasion and preoperative and postoperative tumor burden in previously untreated glioblastoma: Correlation with survival.Surgical neurology international · 2010Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies including tumours of different histological types and grades are however lacking, mostly because reliable physiological invasion assays have been difficult to establish. Using an organotypic rodent brain slice assay, we evaluated the invasiveness of 42 grade II-IV glioma biopsy specimens, and correlated it with the histological phenotype, the absence or presence of deletions on chromosomes 1p and 19q assessed by fluorescent in situ hybridisation, and proliferation and apoptosis indices assessed by immunocytochemistry. Oligodendroglial tumours with 1p/19q loss were less invasive than astrocytic tumours of similar tumour grade. Correlation analysis of invasiveness cell proliferation and apoptosis further suggested that grade II-III oligodendroglial tumours with 1p/19q loss grow in situ as relatively circumscribed compact masses in contrast to the more infiltrative and more diffuse astrocytomas. Lower invasiveness may be an important characteristic of oligodendroglial tumours, adding to our understanding of their more indolent clinical evolution and responsiveness to therapy.
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