ArticleBritish journal of cancer2004
Human herpes virus 6 or Epstein-Barr virus were not detected in Guthrie cards from children who later developed leukaemia.
Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal Infection in Pregnancy and Childhood Leukemia: A Systematic Review and Meta-analysis.The Journal of pediatrics · 2020Pooled it
- Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence.Virology journal · 2022Article
- Association of population mixing and acute lymphocytic leukemia in children and young adults.Cancer epidemiology · 2020Article
- DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation.Scientific reports · 2019Article
- Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing.Haematologica · 2017Article
- In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia.Blood · 2017Article
- Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.British journal of cancer · 2016Article
- EBV, HCMV, HHV6, and HHV7 screening in bone marrow samples from children with acute lymphoblastic leukemia.BioMed research international · 2014Article
- Seroprevalence of human herpes simplex, hepatitis B and epstein-barr viruses in children with acute lymphoblastic leukemia in southern iran.Pathology oncology research : POR · 2010Article
- Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls.British journal of cancer · 2008Article
- Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia.British journal of cancer · 2007Article
- Infectious etiologies of childhood leukemia: plausibility and challenges to proof.Environmental health perspectives · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate if children who later developed acute lymphoblastic leukaemia (ALL) were prenatally infected with HHV-6 and/or EBV, Guthrie cards taken at birth were analysed by PCR. Guthrie cards from 54 patients with ALL and 47 healthy controls matched for age and birth place were tested negative for both HHV-6 and EBV DNA. All samples contained amplifiable DNA when tested by HLA-DQ PCR. Our negative findings suggest that childhood ALL is unlikely to be associated with an in utero infection with EBV or HHV-6.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.