ArticleMolecular biology of the cell2004
Bone marrow stromal cells, preadipocytes, and dermal fibroblasts promote epidermal regeneration in their distinctive fashions.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 101 citations in OpenAlex.
- Development of a tissue-engineered skin model with epidermal, dermal and hypodermal components.In vitro models · 2023Article
- Human umbilical cord mesenchymal stem cell-derived exosomes combined with gelatin methacryloyl hydrogel to promote fractional laser injury wound healing.International wound journal · 2023Article
- Microenvironmental elements singularity synergistically regulate the behavior and chemosensitivity of endometrioid carcinoma.Human cell · 2023Article
- Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization.Biomedical materials & devices (New York, N.Y.) · 2023Article
- Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts.Scientific reports · 2020Article
- Isolation and Characterization of a Human Fetal Mesenchymal Stem Cell Population: Exploring the Potential for Cell Banking in Wound Healing Therapies.Cell transplantation · 2019Article
- Mesenchymal cells and fluid flow stimulation synergistically regulate the kinetics of corneal epithelial cells at the air-liquid interface.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- Current Advancements and Strategies in Tissue Engineering for Wound Healing: A Comprehensive Review.Advances in wound care · 2017Review
- The Effect of Antiseptics on Adipose-Derived Stem Cells.Plastic and reconstructive surgery · 2017Article
- Potential of bone marrow mesenchymal stem cells in rejuvenation of the aged skin of rats.Biomedical reports · 2017Article
- The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair.International journal of biological sciences · 2017Article
- D-dopachrome tautomerase in adipose tissue inflammation and wound repair.Journal of cellular and molecular medicine · 2017Article
- Integration of Mature Adipocytes to Build-Up a Functional Three-Layered Full-Skin Equivalent.Tissue engineering. Part C, Methods · 2016Article
- The macrophage migration inhibitory factor protein superfamily in obesity and wound repair.Experimental & molecular medicine · 2015Review
- Article
- Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1α/IL-6 loop.The Journal of investigative dermatology · 2014Article
- Glucose toxic effects on granulation tissue productive cells: the diabetics' impaired healing.BioMed research international · 2013Review
- Korean mistletoe lectin regulates self-renewal of placenta-derived mesenchymal stem cells via autophagic mechanisms.Cell proliferation · 2012Article
- Periostin promotes chronic allergic inflammation in response to Th2 cytokines.The Journal of clinical investigation · 2012Article
- Human dermis harbors distinct mesenchymal stromal cell subsets.The Journal of investigative dermatology · 2012Article
Corrections and comments
- Erratum issuedCorrection.2015
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal cell types, under mesenchymal-epithelial interaction, are involved in tissue regeneration. Here we show that bone marrow stromal cells (BMSCs), subcutaneous preadipocytes, and dermal fibroblasts distinctively caused keratinocytes to promote epidermal regeneration, using a skin reconstruction model by their coculture with keratinocytes. Three mesenchymal cell types promoted the survival, growth, and differentiation of keratinocytes, whereas BMSCs and preadipocytes inhibited their apoptosis. BMSCs and preadipocytes induced keratinocytes to reorganize rete ridge- and epidermal ridge-like structures, respectively. Keratinocytes with fibroblasts or BMSCs expressed the greatest amount of interleukin (IL)-1alpha protein, which is critical for mesenchymal-epithelial cross-talk in skin. Keratinocytes with or without three mesenchymal supports displayed another cross-talk molecule, c-Jun protein. Without direct mesenchymal-epithelial contact, the rete ridge- and epidermal ridge-like structures were not replicated, whereas the other phenomena noted above were. DNA microarray analysis showed that the mesenchymal-epithelial interaction affected various gene expressions of keratinocytes and mesenchymal cell types. Our results suggest that not only skin-localized fibroblasts and preadipocytes but also BMSCs accelerate epidermal regeneration in complexes and that direct contact between keratinocytes and BMSCs or preadipocytes is required for the skin-specific morphogenesis above, through mechanisms that differ from the IL-1alpha/c-Jun pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.