ArticleNucleic acids research2004
The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Interpreting the Origins and Functions of Noncoding RNAs From the Ribosomal Genes.Journal of cellular physiology · 2025Review
- The Nucleolus: A Central Hub for Ribosome Biogenesis and Cellular Regulatory Signals.International journal of molecular sciences · 2025Review
- Article
- Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins.PLoS pathogens · 2022Article
- Antagonising Chromatin Remodelling Activities in the Regulation of Mammalian Ribosomal Transcription.Genes · 2021Review
- The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites.The Yale journal of biology and medicine · 2019Article
- Genome Organization in and around the Nucleolus.Cells · 2019Review
- Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication.BMB reports · 2018Article
- Nucleolar responses to DNA double-strand breaks.Nucleic acids research · 2016Review
- Analysis of histone modifications at human ribosomal DNA in liver cancer cell.Scientific reports · 2015Article
- Review
- Chromatin targeting signals, nucleosome positioning mechanism and non-coding RNA-mediated regulation of the chromatin remodeling complex NoRC.PLoS genetics · 2014Article
- Large-scale organization of ribosomal DNA chromatin is regulated by Tip5.Nucleic acids research · 2013Article
- Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites.PLoS genetics · 2013Article
- Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription.Nucleic acids research · 2012Article
- The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast.The EMBO journal · 2012Article
- Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.The Journal of biological chemistry · 2012Article
- Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.Molecular & cellular proteomics : MCP · 2012Article
- Identification and characterization of ToRC, a novel ISWI-containing ATP-dependent chromatin assembly complex.Genes & development · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription termination factor (TTF)-I is a multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. TTF-I plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. The N-terminal part of TTF-I contains a negative regulatory domain (NRD) that inhibits DNA binding. Here we show that interactions between the NRD and the C-terminal part of TTF-I mask the DNA-binding domain of TTF-I. However, interaction with TIP5, a subunit of the nucleolar chromatin remodeling complex, NoRC, recovers DNA-binding activity. We have mapped the protein domains that mediate the interaction between TTF-I and TIP5. The association of TIP5 with the NRD facilitates DNA binding of TTF-I and leads to the recruitment of NoRC to the rDNA promoter. Thus, TTF-I and NoRC act in concert to silence rDNA transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.