ArticleJournal of bacteriology2004
Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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86 citing papers in PubMed.
- Released palmitic acid-mediated TLR4/NF-κB activation enhances the virulence of Bordetella pertussis MT28 lineage.Nature communications · 2026Article
- Genomic surveillance reveals global spread of macrolide-resistantJournal of clinical microbiology · 2025Article
- Sharp rise in high-virulence Bordetella pertussis with macrolides resistance in Northern China.Emerging microbes & infections · 2025Article
- Molecular epidemiology and increasing macrolide resistance of Bordetella pertussis isolates in Guangzhou, China.BMC infectious diseases · 2025Article
- Macrolide-ResistantMicroorganisms · 2025Article
- Pertussis vaccines, epidemiology and evolution.Nature reviews. Microbiology · 2024Review
- Whole-genome comparison of two same-genotype macrolide-resistant Bordetella pertussis isolates collected in Japan.PloS one · 2024Article
- Vaccine Antigen Deficiency Does Not Substantially Affect the Identification of Bordetella pertussis Strains by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.Journal of clinical microbiology · 2023Article
- Genotypic Analysis of the Population Structure inJournal of fungi (Basel, Switzerland) · 2023Article
- Suspicions of two bridgehead invasions of Xylella fastidiosa subsp. multiplex in France.Communications biology · 2023Article
- Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016-2022.Emerging infectious diseases · 2023Article
- Genotypes ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Article
- Macrolide susceptibility and molecular characteristics ofThe Journal of international medical research · 2022Article
- A Cross-Sectional Study Revealing the Emergence of Erythromycin-ResistantFrontiers in microbiology · 2022Article
- Genomic Surveillance and Improved Molecular Typing of Bordetella pertussis Using wgMLST.Journal of clinical microbiology · 2021Article
- Rapid and simple SNP genotyping for Bordetella pertussis epidemic strain MT27 based on a multiplexed single-base extension assay.Scientific reports · 2021Article
- High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014-2016.Emerging infectious diseases · 2019Article
- Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina.Emerging infectious diseases · 2019Article
- Genomic Survey of Bordetella pertussis Diversity, United States, 2000-2013.Emerging infectious diseases · 2019Article
- Population dynamics and antigenic drift ofEmerging microbes & infections · 2019Article
26 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Bordetella pertussis, the causative agent of whooping cough, has remained endemic in The Netherlands despite extensive nationwide vaccination since 1953. In the 1990s, several epidemic periods have resulted in many cases of pertussis. We have proposed that strain variation has played a major role in the upsurges of this disease in The Netherlands. Therefore, molecular characterization of strains is important in identifying the causes of pertussis epidemiology. For this reason, we have developed a multiple-locus variable-number tandem repeat analysis (MLVA) typing system for B. pertussis. By combining the MLVA profile with the allelic profile based on multiple-antigen sequence typing, we were able to further differentiate strains. The relationships between the various genotypes were visualized by constructing a minimum spanning tree. MLVA of Dutch strains of B. pertussis revealed that the genotypes of the strains isolated in the prevaccination period were diverse and clearly distinct from the strains isolated in the 1990s. Furthermore, there was a decrease in diversity in the strains from the late 1990s, with a remarkable clonal expansion that coincided with the epidemic periods. Using this genotyping, we have been able to show that B. pertussis is much more dynamic than expected.
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