ArticleJournal of bacteriology2004
Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivo.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores.Frontiers in molecular biosciences · 2024Article
- Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives.Molecules (Basel, Switzerland) · 2020Article
- Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action.British journal of pharmacology · 2019Review
- Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.Tuberculosis (Edinburgh, Scotland) · 2018Article
- Article
- Does Concurrent Use of Some Botanicals Interfere with Treatment of Tuberculosis?Neuromolecular medicine · 2016Review
- Using a Label Free Quantitative Proteomics Approach to Identify Changes in Protein Abundance in Multidrug-Resistant Mycobacterium tuberculosis.Indian journal of microbiology · 2015Article
- Proteome turnover in bacteria: current status for Corynebacterium glutamicum and related bacteria.Microbial biotechnology · 2013Review
- Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N.PloS one · 2013Article
- Bilirubin: An Endogenous Molecule with Antiviral Activity in vitro.Frontiers in pharmacology · 2012Article
- Depletion of antibiotic targets has widely varying effects on growth.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase.Biochemistry · 2008Article
- Stimulation of phagocytic activity of alveolar macrophages toward artificial microspheres by infection with mycobacteria.Pharmaceutical research · 2008Article
- Molecular and physiological effects of mycobacterial oxyR inactivation.Journal of bacteriology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Isoniazid (INH), a front-line antituberculosis agent, is activated by mycobacterial catalase-peroxidase KatG, converting INH into bactericidal reactive species. Here we investigated the requirements and the pathway of nitric oxide (NO*) generation during oxidative activation of INH by Mycobacterium tuberculosis KatG in vitro. We also provide in vivo evidence that INH-derived NO* can inhibit key mycobacterial respiratory enzymes, which may contribute to the overall antimycobacterial action of INH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.