Evidence map›Paper›PMID 15289931›Full record

ReviewCellular and molecular life sciences : CMLS2004

Structure-based models of cadherin-mediated cell adhesion: the evolution continues.

A W Koch, K L Manzur, W Shan

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The Influence of Heat-KilledFrontiers in microbiology · 2019
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
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  14. Article
  15. The vascular system as a target of metal toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2008
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

A W KochMontreal Neurological Institute, McGill University, 3801 University Street, H3A 2B4, Montreal, Quebec, Canada. akoch@gene.com
K L Manzur
W Shan
Montreal Neurological Institute and Hospital · CAIcahn School of Medicine at Mount Sinai · US

Funding

STRUCTURE OF PROTEIN MODULES IN CHROMATIN REMODELINGR01CA087658 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI ZHOU, MING-MING · 2000 to 2016
$4.8M
Protein Components of the Synaptic Adhesive ScaffoldR01NS041687 · NINDS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI COLMAN, DAVID R · 2001 to 2005
$2.1M
BIOSYNTHESIS AND ASSEMBLY OF MYELIN MEMBRANE PROTEINSR01NS020147 · NINDS · NEW YORK UNIVERSITY · PI COLMAN, DAVID R · 1985 to 2006
$2.0M
NCI NIH HHS CA87658NINDS NIH HHS NS20147NINDS NIH HHS NS41687
6 · The paper itself

Abstract

Cadherins are glycoproteins that are responsible for homophilic, Ca2+-dependent cell-cell adhesion and play crucial roles in many cellular adhesion processes ranging from embryogenesis to the formation of neuronal circuits in the central nervous system. Many different experimental approaches have been used to unravel the molecular basis for cadherin-mediated adhesion. In particular, several high-resolution structures have provided models for cadherin-cadherin interactions that are illuminative in many respects yet contradictory in others. This review gives an overview of the structural studies of cadherins over the past decade while focusing on recent developments that reconcile some of the earlier findings.

Indexed as

AnimalsCadherinsCalciumCell AdhesionDesmosomesDiagnostic ImagingHumansModels, BiologicalProtein Structure, TertiaryStructure-Activity RelationshipCadherinsCalcium

Identifiers

PMID15289931
PMCPMC11138478
OpenAlexW2000560224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.