ReviewCellular and molecular life sciences : CMLS2004
Apoptosis regulation in the mammary gland.
Review in Cellular and molecular life sciences : CMLS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 101 citations in OpenAlex.
- Low- and high-dose-rate radiation exposure alters the cellular composition and dynamics of the rat mammary epithelium for weeks preceding carcinogenesis.Journal of radiation research · 2026Article
- Article
- Article
- Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Review
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- Microglial Corpse Clearance: Lessons From Macrophages.Frontiers in immunology · 2020Review
- Cysteine Dioxygenase Regulates the Epithelial Morphogenesis of Mammary Gland via Cysteine Sulfinic Acid.iScience · 2019Article
- Integrative Analysis of Transcriptome and GWAS Data to Identify the Hub Genes Associated With Milk Yield Trait in Buffalo.Frontiers in genetics · 2019Article
- PD-1 Blockade During Post-partum Involution Reactivates the Anti-tumor Response and Reduces Lymphatic Vessel Density.Frontiers in immunology · 2019Article
- Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis.Journal of exercise nutrition & biochemistry · 2015Article
- Article
- Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.Development (Cambridge, England) · 2012Article
- The anti-metastatic nm23-1 gene is needed for the final step of mammary duct maturation of the mouse nipple.PloS one · 2011Article
- TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.PloS one · 2011Article
- Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax.Genesis (New York, N.Y. : 2000) · 2011Article
- Article
- Cell-matrix interactions in mammary gland development and breast cancer.Cold Spring Harbor perspectives in biology · 2010Review
- Analysis of inhibitor of apoptosis protein family expression during mammary gland development.BMC developmental biology · 2010Article
- Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial apoptosis has a key role in the development and function of the mammary gland. It is involved with the formation of ducts during puberty and is required to remove excess epithelial cells after lactation so that the gland can be prepared for future pregnancies. Deregulated apoptosis contributes to malignant progression in the genesis of breast cancer. Since epithelial cell apoptosis in the lactating mammary gland can be synchronised by forced weaning, it has been possible to undertake biochemical analysis of the pathways involved. Together with the targeted overexpression or deletion of candidate genes, these approaches have provided a unique insight into the complex mechanisms of apoptosis regulation in vivo. This review explores what is currently known about the triggers for apoptosis in the normal mammary gland, and how they link with the intrinsic apoptotic machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.