ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2004
Chromosomal dynamics of human neocentromere formation.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed.
- Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and chromosome missegregation.Cell reports · 2026Article
- Characterization of neocentromeric marker chromosome derived from chromosome 11: a rare entity in four patients with acute leukemia.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Increased maize chromosome number by engineered chromosome fission.Science advances · 2025Article
- Prenatal identification of an inverted duplicated 13q marker chromosome with a neocentromere.Molecular cytogenetics · 2023Article
- Centromere Chromatin Dynamics at a Glance.Epigenomes · 2022Review
- Expanding studies of chromosome structure and function in the era of T2T genomics.Human molecular genetics · 2021Review
- Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin.International journal of molecular sciences · 2021Review
- Biochemical evidence for diverse strategies in the inner kinetochore.Open biology · 2020Review
- Centromere deletion ineLife · 2020Article
- A role of the Trx-G complex in Cid/CENP-A deposition at Drosophila melanogaster centromeres.Chromosoma · 2019Article
- Centromere Repeats: Hidden Gems of the Genome.Genes · 2019Review
- Going the distance: Neocentromeres make long-range contacts with heterochromatin.The Journal of cell biology · 2019Article
- Plant centromeres: genetics, epigenetics and evolution.Molecular biology reports · 2018Review
- Posttranslational modifications of CENP-A: marks of distinction.Chromosoma · 2018Review
- Article
- Human centromere repositioning within euchromatin after partial chromosome deletion.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
- No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation.Cellular and molecular life sciences : CMLS · 2016Review
- CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres.Nature structural & molecular biology · 2016Article
- Tetrasomy 3q26.32-q29 due to a supernumerary marker chromosome in a child with pigmentary mosaicism of Ito.Genetics and molecular biology · 2016Article
- Molecular characterization of a rare analphoid supernumerary marker chromosome derived from 7q35 → qter: a case report.Molecular cytogenetics · 2016Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Neocentromeres are rare human chromosomal aberrations where a new centromere has formed in a previously non-centromeric location. The emergence of new centromeres on a chromosome that already contains an endogenous centromere would be a highly deleterious event which would lead to dicentricity and mitotic instability. Nonetheless, neocentromere formation appears to provide a mechanism for the acquisition of a new centromere. Neocentromeres are most often observed on chromosomal arm fragments that have separated from an endogenous centromere, and therefore actually lead to mitotic stability of what would have been an acentric fragment. Neocentromeres have recently also been observed on apparently unrearranged chromosomes where the endogenous centromere has been inactivated. Furthermore, the process of centromere repositioning during primate chromosomal evolution may depend on the acquisition and subsequent fixation of neocentromeres. This remarkable plasticity in the position of centromeres has important implications for human cytogenetics and chromosome evolution, and provides an opportunity to further our understanding of the process of centromere formation and structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.