ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2004
Kinetochore-microtubule interactions during cell division.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression.Current biology : CB · 2023Article
- An integrative multi-omics analysis based on liquid-liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature.Journal of translational medicine · 2022Article
- CsKTN1 for a katanin p60 subunit is associated with the regulation of fruit elongation in cucumber (Cucumis sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Comparative Transcriptome Analysis Reveals Molecular Basis Underlying Fast Growth of the Selectively Bred Pacific Oyster,Frontiers in genetics · 2019Article
- The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy.Oncotarget · 2016Article
- Transcriptomic analysis reveals the roles of microtubule-related genes and transcription factors in fruit length regulation in cucumber (Cucumis sativus L.).Scientific reports · 2015Article
- Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin.Oncogene · 2012Article
- Augmin promotes meiotic spindle formation and bipolarity in Xenopus egg extracts.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Merotelic attachments and non-homologous end joining are the basis of chromosomal instability.Cell division · 2010Article
- Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Chromosome congression in the absence of kinetochore fibres.Nature cell biology · 2009Article
- Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis.Molecular biology of the cell · 2009Article
- The ultrastructure of the kinetochore and kinetochore fiber in Drosophila somatic cells.Chromosoma · 2006Article
- Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosis.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper segregation of chromosomes during cell division is essential for the maintenance of genetic stability. During this process chromosomes must establish stable functional interactions with microtubules through the kinetochore, a specialized protein structure located on the surface of the centromeric heterochromatin. Stable attachment of kinetochores to a number of microtubules results in the formation of a kinetochore fibre that mediates chromosome movement. How the kinetochore fibre is formed and how chromosome motion is produced and regulated remain major questions in cell biology. Here we look at some of the history of research devoted to the study of kinetochore-microtubule interaction and attempt to identify significant advances in the knowledge of the basic processes. Ultrastructural work has provided substantial insights into the structure of the kinetochore and associated microtubules during different stages of mitosis. Also, recent in-vivo studies have probed deep into the dynamics of kinetochore-attached microtubules suggesting possible models for the way in which kinetochores harness the capacity of microtubules to do work and turn it into chromosome motion. Much of the research in recent years suggests that indeed multiple mechanisms are involved in both formation of the k-fibre and chromosome motion. Thus, rather than moving to a unified theory, it has become apparent that most cell types have the capacity to build the spindle using multiple and probably redundant mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.