ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2004
The roles of histone modifications and small RNA in centromere function.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Programmed DNA elimination in the parasitic nematode Ascaris.PLoS pathogens · 2023Review
- The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.Nature communications · 2020Article
- Nondisjunction in favor of a chromosome: the mechanism of rye B chromosome drive during pollen mitosis.The Plant cell · 2012Article
- The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background.Developmental biology · 2011Article
- Hairpin dsRNA does not trigger RNA interference in Candida albicans cells.Yeast (Chichester, England) · 2011Article
- Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.BMC molecular biology · 2010Article
- Coordinating cohesion, co-orientation, and congression during meiosis: lessons from holocentric chromosomes.Genes & development · 2010Review
- An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.Molecular cell · 2009Article
- The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans.BMC developmental biology · 2007Article
- MicroRNAs in gene regulation: when the smallest governs it all.Journal of biomedicine & biotechnology · 2006Article
- Role of the silkworm argonaute2 homolog gene in double-strand break repair of extrachromosomal DNA.Nucleic acids research · 2006Article
- Artificial and engineered chromosomes: developments and prospects for gene therapy.Chromosoma · 2005Review
- The role of heterochromatin in centromere function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, epigenetic regulation of centromeric chromatin in fission yeast (Schizosaccharomyces pombe) is reviewed, focussing on the role of histone modifications and the link to RNA interference (RNAi). Fission yeast centromeres are organized into two structurally and functionally distinct domains, both of which are required for centromere function. The central core domain anchors the kinetochore structure while the flanking heterochromatin domain is important for sister centromere cohesion. The chromatin structure of both domains is regulated epigenetically. In the central core domain, the histone H3 variant Cnp1(CENP-A) plays a key role. In the flanking heterochromatin domain, histones are kept underacetylated by the histone deacetylases (HDACs) Clr3, Clr6 and Sir2, and methylated by Clr4 methyltransferase (HMTase) to create a specific binding site for the Swi6 protein. Swi6 then directly mediates cohesin binding to the centromeric heterochromatin. Recently, a surprising link was made between heterochromatin formation and RNAi.
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