ArticleProceedings of the National Academy of Sciences of the United States of America2004
Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Genome-wide analysis reveals the importance of histone acetyltransferase Esa1 in transcriptional regulation during nitrogen starvation.bioRxiv : the preprint server for biology · 2026Article
- Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces cerevisiae for Global Proteomic Analysis.Analytical chemistry · 2018Article
- The role of Rubisco kinetics and pyrenoid morphology in shaping the CCM of haptophyte microalgae.Journal of experimental botany · 2017Article
- Inositol phosphate multikinase dependent transcriptional control.Advances in biological regulation · 2017Article
- Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.Genome research · 2016Article
- Checkpoint kinases regulate a global network of transcription factors in response to DNA damage.Cell reports · 2013Article
- Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species.Eukaryotic cell · 2013Article
- Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.Genetics · 2012Article
- SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Promoter regulation by distinct mechanisms of functional interplay between lysine acetylase Rtt109 and histone chaperone Asf1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment.Biochemical and biophysical research communications · 2009Article
- GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.The Journal of biological chemistry · 2008Article
- Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis.Genetics · 2008Article
- Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.Advances in enzyme regulation · 2007Review
- Activation of Saccharomyces cerevisiae HIS3 results in Gcn4p-dependent, SWI/SNF-dependent mobilization of nucleosomes over the entire gene.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Transcription of the arginine biosynthetic gene ARG1 is repressed by the ArgR/Mcm1p complex in arginine-replete cells and activated by Gcn4p, a transcription factor induced by starvation for any amino acid. We show that all four subunits of the arginine repressor are recruited to ARG1 by Gcn4p in cells replete with arginine but starved for isoleucine/valine. None of these proteins is recruited to the Gcn4p target genes ARG4 and SNZ1, which are not regulated by ArgR/Mcm1p. Mcm1p and Arg80p were found in a soluble complex lacking Arg81p and Arg82p, and both Mcm1p and Arg80p were efficiently recruited to ARG1 in wild-type cells in the presence or absence of exogenous arginine, and also in arg81Delta cells. By contrast, the recruitment of Arg81p and Arg82p was stimulated by exogenous arginine. These findings suggest that Gcn4p constitutively recruits an Mcm1p/Arg80p heterodimer and that efficient assembly of a functional repressor also containing Arg81p and Arg82p occurs only in arginine excess. By recruiting an arginine-regulated repressor, Gcn4p can precisely modulate its activation function at ARG1 according to the availability of arginine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.