ArticleProceedings of the National Academy of Sciences of the United States of America2004
Evolutionary genomics of ecological specialization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 113 citations in OpenAlex.
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- Transposable Elements Mediate Adaptive Debilitation of Flagella in Experimental Escherichia coli Populations.Journal of molecular evolution · 2017Article
- Molecular and cellular bases of adaptation to a changing environment in microorganisms.Proceedings. Biological sciences · 2016Review
- Thoughts Toward a Theory of Natural Selection: The Importance of Microbial Experimental Evolution.Cold Spring Harbor perspectives in biology · 2016Review
- Evolution in spatially mixed host environments increases divergence for evolved fitness and intrapopulation genetic diversity in RNA viruses.Virus evolution · 2016Article
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- Synthetic and Evolutionary Construction of a Chlorate-Reducing Shewanella oneidensis MR-1.mBio · 2015Article
- The functional basis of adaptive evolution in chemostats.FEMS microbiology reviews · 2015Review
- Ex uno plures: clonal reinforcement drives evolution of a simple microbial community.PLoS genetics · 2014Article
- The dynamics of diverse segmental amplifications in populations of Saccharomyces cerevisiae adapting to strong selection.G3 (Bethesda, Md.) · 2014Article
- Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments.PLoS genetics · 2014Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used a combination of genomic techniques to monitor chromosomal evolution across hundreds of generations as Escherichia coli adapted to growth-limiting concentrations of either lactulose, methyl-galactoside, or a 72:28 mixture of the two. DNA microarrays identified 8 unique duplications and 16 unique deletions among 42 evolvants from 23 chemostat experiments. Each mutation was confirmed by sequencing PCR-amplified flanking genomic DNA and, except for one deletion, an insertion sequence was found at the break point. vPCR of insertion sequences identified these same mutations and 16 additional insertions (all confirmed by sequencing). The pattern of genomic evolution is highly reproducible. Statistical analyses show that duplications at lac and mutations in mgl are adaptations specific to lactulose and to methyl-galactoside, respectively. Adaptation to mixed sugars is characterized by similar mutations, but lac duplications and mgl mutations usually arise in different backgrounds, producing ecological specialists for each sugar. This suggests that an antagonistic pleiotropic tradeoff between duplications at lac and mutations in mgl retards the evolution of generalists. Other mutations that repeatedly appear in replicate experiments are adaptations to the chemostat environment and are not specific to one or the other sugar.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.