ArticleThe Journal of cell biology2004
Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
- Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities.Frontiers in endocrinology · 2024Review
- Myoblasts With Higher IRS-1 Levels Are Eliminated From the Normal Cell Layer During Differentiation.Frontiers in endocrinology · 2020Article
- αMolecular cancer research : MCR · 2019Article
- Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy.International journal of molecular sciences · 2015Review
- αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression.The Biochemical journal · 2015Article
- Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation.Cellular and molecular life sciences : CMLS · 2014Review
- Calreticulin affects cell adhesiveness through differential phosphorylation of insulin receptor substrate-1.Cellular & molecular biology letters · 2014Article
- Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2.Cancer research · 2014Article
- β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1.Journal of cellular physiology · 2013Article
- Article
- Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis.Journal of cellular physiology · 2012Article
- PSA regulates androgen receptor expression in prostate cancer cells.The Prostate · 2012Article
- Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels.The Journal of biological chemistry · 2012Article
- Insulin-like growth factor 1 stimulation of androgen receptor activity requires β(1A) integrins.Journal of cellular physiology · 2012Article
- Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances.Frontiers in endocrinology · 2012Article
- β1 integrin deletion enhances progression of prostate cancer in the TRAMP mouse model.Scientific reports · 2012Article
- Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis.Oncogene · 2011Article
- Significance of talin in cancer progression and metastasis.International review of cell and molecular biology · 2011Review
- The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
We show here that beta1 integrins selectively modulate insulin-like growth factor type I receptor (IGF-IR) signaling in response to IGF stimulation. The beta1A integrin forms a complex with the IGF-IR and insulin receptor substrate-1 (IRS-1); this complex does not promote IGF-I mediated cell adhesion to laminin (LN), although it does support IGF-mediated cell proliferation. In contrast, beta1C, an integrin cytoplasmic variant, increases cell adhesion to LN in response to IGF-I and its down-regulation by a ribozyme prevents IGF-mediated adhesion to LN. Moreover, beta1C completely prevents IGF-mediated cell proliferation and tumor growth by inhibiting IGF-IR auto-phosphorylation in response to IGF-I stimulation. Evidence is provided that the beta1 cytodomain plays an important role in mediating beta1 integrin association with either IRS-1 or Grb2-associated binder1 (Gab1)/SH2-containing protein-tyrosine phosphate 2 (Shp2), downstream effectors of IGF-IR: specifically, beta1A associates with IRS-1 and beta1C with Gab1/Shp2. This study unravels a novel mechanism mediated by the integrin cytoplasmic domain that differentially regulates cell adhesion to LN and cell proliferation in response to IGF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.