ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2004
Virological surveillance of influenza-like illness in the community using PCR and serology.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis.Epidemiology and infection · 2020Pooled it
- Influenza, influenza-like symptoms and their association with cardiovascular risks: a systematic review and meta-analysis of observational studies.International journal of clinical practice · 2015Pooled it
- Evaluating the impact of coronavirus disease 2019 on asthma morbidity: A comprehensive analysis of potential influencing factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Article
- Epidemiology and phylogenetic analysis of respiratory viruses from 2012 to 2015 - A sentinel surveillance report from union territory of Puducherry, India.Clinical epidemiology and global health · 2020Article
- Quantifying the causal impact of funding bedside antigen testing on the incidence of respiratory syncytial virus infection in Japan: a difference-in-differences study.Annals of translational medicine · 2020Article
- Detection of influenza-like illness aberrations by directly monitoring Pearson residuals of fitted negative binomial regression models.BMC public health · 2015Article
- Clinical evaluation of viral acute respiratory tract infections in children presenting to the emergency department of a tertiary referral hospital in the Netherlands.BMC pediatrics · 2014Article
- in silico surveillance: evaluating outbreak detection with simulation models.BMC medical informatics and decision making · 2013Article
- The post-infection outcomes of influenza and acute respiratory infection in patients above 50 years of age in Japan: an observational study.Influenza and other respiratory viruses · 2012Article
- Rapid detection of respiratory tract viral infections and coinfections in patients with influenza-like illnesses by use of reverse transcription-PCR DNA microarray systems.Journal of clinical microbiology · 2010Article
- Low clinical burden of 2009 pandemic influenza A (H1N1) infection during pregnancy on the island of La Réunion.PloS one · 2010Article
- Estimating sensitivity of laboratory testing for influenza in Canada through modelling.PloS one · 2009Article
- Evaluation of a multiplexed PCR assay for detection of respiratory viral pathogens in a public health laboratory setting.Journal of clinical microbiology · 2007Article
- Surveillance of respiratory virus infections in adult hospital admissions using rapid methods.Epidemiology and infection · 2006Article
- Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2005Article
- [Managing lower respiratory tract infections in immunocompetent patients. Definitions, epidemiology, and diagnostic features].Medecine et maladies infectieusesReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurveillance of winter respiratory viral illness has been carried out for nearly 30 years using a clinical diagnosis by general practitioners as part of the Scottish Sentinel General Practice (SSGP) network. Contemparaneous laboratory diagnosis has not been available previously.
objectivesTo assess the proportion of influenza-like illness (ILI) attributable to influenza, respiratory syncytial virus (RSV) and picornavirus infection during the winter season. To compare the influenza PCR data with serology of paired blood samples. STUDY
designCombined nose and throat swabs, from patients with ILI attending 15 general practices across Scotland, were submitted to the laboratory in virus PCR sample solution (VPSS). The extracted nucleic acid was tested using a multiplex reverse-transcription polymerase chain reaction (RT-PCR) assay. Serological analysis was performed on paired serum samples using complement fixation assays. The rate of influenza virus positivity was compared with reports of ILI obtained from the SSGP network.
resultsOf 240 samples received at the laboratory, 132 (55%) were PCR positive for influenza A virus. There were nine (3.8%) picornavirus and three (1.2%) RSV PCR positives, two (0.8%) were dual influenza A/picornavirus infections. Ninety four (39.2%) were negative for all viruses tested. Results on paired sera from 89 patients showed a rising titre to influenza A in 48 of the 57 PCR positive samples (84.2%). One PCR negative patient displayed a significant rising titre to influenza A. Virological data paralleled the SSGP data but was available at least a week earlier.
conclusionsInfluenza A infection was detected in the majority of patients with ILI; picornavirus infection was also shown to be an important cause of illness. PCR is a rapid and sensitive method for respiratory virus surveillance. Serology is slow, insensitive and difficult to interpret at low titres.
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