ReviewDrugs & aging2004
Poststroke epilepsy: epidemiology, pathophysiology and management.
Review in Drugs & aging, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Analysis of risk factors for first seizure after stroke in Chinese patients.BioMed research international · 2013Trial
- [Post-stroke epilepsy: First data from Niger].Medecine tropicale et sante internationale · 2025Article
- Nrf2 and Ferroptosis: Exploring Translational Avenues for Therapeutic Approaches to Neurological Diseases.Current drug targets · 2025Review
- Causal associations of ischemic stroke, metabolic factors, and related medications with epilepsy: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Article
- Study on the association between pregnancy-associated plasma protein-A and acute cerebral infarction.Frontiers in neurology · 2023Article
- Application of physiologically-based pharmacokinetic model approach to predict pharmacokinetics and drug-drug interaction of rivaroxaban: A case study of rivaroxaban and carbamazepine.CPT: pharmacometrics & systems pharmacology · 2022Article
- Effects of Carbamazepine and Phenytoin on Pharmacokinetics and Pharmacodynamics of Rivaroxaban.Pharmaceutics · 2020Article
- The influence of statins on the risk of post-stroke epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Seizures Do Not Affect Disability and Mortality Outcomes of Stroke: A Population-Based Study.Journal of clinical medicine · 2019Article
- Epilepsy in the Elderly: Treatment and Consideration of Comorbid Diseases.Journal of epilepsy research · 2019Review
- Seizure in cerebral venous and sinus thrombosis.Epilepsia open · 2018Review
- The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study.Journal of neurology · 2018Article
- [Epileptic seizures and epilepsy after a stroke : Incidence, prevention and treatment].Der Nervenarzt · 2017Review
- Mortality after primary intracerebral hemorrhage in relation to post-stroke seizures.Journal of neurology · 2017Article
- Animal Models of Posttraumatic Seizures and Epilepsy.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Does treatment with t-PA increase the risk of developing epilepsy after stroke?Journal of neurology · 2015Observational
- Profile of epilepsy in a regional hospital in Al qassim, saudi arabia.International journal of health sciences · 2014Article
- Prognostic value of early epileptic seizures on mortality and functional disability in acute stroke: the Dijon Stroke Registry (1985-2010).Journal of neurology · 2013Article
- Acute seizures in acute ischemic stroke: does thrombolysis have a role to play?Journal of neurology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seizures and status epilepticus can be a presenting feature of acute stroke. They may occur in its early (<7 days) clinical course or be a remote (>7 days) complication. Most seizures are single, either partial or generalised. Early and remote seizures seem to have different predictors and pathogenesis. Seizures are more frequent in severe and disabling strokes, haemorrhagic strokes and those with cortical involvement. The risk of epilepsy is higher for patients with early seizures, cortical infarctions and lobar haemorrhages and in dependent patients. Early or remote seizures do not have a significant influence on dependency or mortality, although seizures and status epilepticus can be a direct cause of death. Treatment can be started after a first or a recurrent seizure. Treatment options include phenytoin, carbamazepine, valproic acid (valproate sodium) and the new antiepileptic drugs (AEDs). New AEDs can be used to decrease the likelihood of drug interactions and adverse effects in patients who do not tolerate the classic AEDs and in treatment failures with classic AEDs. Large observational studies to define prognostic factors for poststroke seizures in specific stroke subtypes are needed. Randomised controlled trials of AED prophylaxis for acute and remote seizures are essential to improve the evidence level of current guidelines and recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.