ArticleOncogene2004
Inhibitory effects of cyclosporin A on calcium mobilization-dependent interleukin-8 expression and invasive potential of human glioblastoma U251MG cells.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells.Scientific reports · 2019Article
- Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion.British journal of pharmacology · 2017Article
- Necrotic cells influence migration and invasion of glioblastoma via NF-κB/AP-1-mediated IL-8 regulation.Scientific reports · 2016Article
- Interleukins in glioblastoma pathophysiology: implications for therapy.British journal of pharmacology · 2013Review
- Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.PloS one · 2013Article
- Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.Molecular biology of the cell · 2012Article
- Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.Journal of signal transduction · 2012Article
- Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB.Journal of neuro-oncology · 2011Article
- IL-8 is a mediator of NF-κB induced invasion by gliomas.Journal of neuro-oncology · 2011Article
- Calcineurin promotes proliferation, migration, and invasion of small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2010Article
- The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma.Oncogene · 2009Article
- Production of angiogenic factors by human glioblastoma cells following activation of the G-protein coupled formylpeptide receptor FPR.Journal of neuro-oncology · 2008Article
- Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotype.Journal of neuro-oncology · 2007Article
- The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.Neuro-oncology · 2005Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-8 produced from glioblastoma is suggested to contribute to its own proliferation and progression. Since various external stimuli have been shown to increase intracellular Ca(2+) in glioma cells, we investigated Ca(2+) mobilization-dependent IL-8 expression and effect of cyclosporin A (CsA), an inhibitor of calcineurin (Cn), on the expression and invasive potential of human glioblastoma U251MG cells. Combined treatment with Ca(2+)-ionophore and phorbol-myristate-acetate (A23187/PMA) increased IL-8 mRNA and protein levels. This increase was suppressed by CsA and by another Cn inhibitor FK506. Luciferase reporter gene assay and electrophoretic mobility shift assay revealed that activation of p65-containing nuclear factor-kappaB was essential for A23187/PMA-dependent activation of IL-8 promoter. CsA suppressed the promoter activity by attenuating IkappaB-alpha degradation. U251MG cells expressed IL-8 receptors CXCR-1 and -2, and Matrigel invasion assay revealed that CsA attenuated A23187/PMA-dependent stimulation of invasive potential, probably by inhibiting IL-8 production. In addition, IL-8-dependent proliferation was also suppressed by CsA. Taken together, these results demonstrate the novel inhibitory effects of CsA on glioblastoma cell functions, suggesting CsA as a potential therapeutic adjuvant for glioma treatment.
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