ArticleOncogene2004
Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation.Molecular oncology · 2025Article
- Role of PHB2 as a potential biomarker in pan-cancer: a multi-database analysis.Scientific reports · 2025Article
- Prohibitions in the meta-inflammatory response: a review.Frontiers in molecular biosciences · 2024Review
- Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis.Journal of the American Heart Association · 2021Article
- Prohibitin 1 in liver injury and cancer.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- P-MAPA and IL-12 Differentially Regulate Proteins Associated with Ovarian Cancer Progression: A Proteomic Study.ACS omega · 2019Article
- Acute psychological stress increases serum circulating cell-free mitochondrial DNA.Psychoneuroendocrinology · 2019Article
- Mitophagy in Cancer: A Tale of Adaptation.Cells · 2019Review
- A novel prognostic marker and immunogenic membrane antigen: prohibitin (PHB) in pancreatic cancer.Clinical and translational gastroenterology · 2018Article
- Recent insights into the actions of IGFBP-6.Journal of cell communication and signaling · 2015Article
- Mitochondrial dysfunction in cancer.Przeglad menopauzalny = Menopause review · 2014Review
- Prohibitin Interacts with envelope proteins of white spot syndrome virus and prevents infection in the red swamp crayfish, Procambarus clarkii.Journal of virology · 2013Article
- Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration.The Journal of biological chemistry · 2013Article
- Follicular stage-dependent regulation of apoptosis and steroidogenesis by prohibitin in rat granulosa cells.Journal of ovarian research · 2013Article
- Prohibitin ligands in cell death and survival: mode of action and therapeutic potential.Chemistry & biology · 2013Review
- The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients.Oncogene · 2012Article
- Prohibitin is overexpressed in Huh-7-HCV and Huh-7.5-HCV cells harboring in vitro transcribed full-length hepatitis C virus RNA.Virology journal · 2011Article
- The role and therapeutic potential of prohibitin in disease.Biochimica et biophysica acta · 2011Review
- Comparative genome analysis of PHB gene family reveals deep evolutionary origins and diverse gene function.BMC bioinformatics · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis of cancer is crucial for successful treatment. Noninvasive assays for detecting tumor-derived antigens in serum and other bodily fluids have the potential to screen healthy individuals for hitherto undetected cancers. Very few such assays have been successfully developed, in part because identifying potential target antigens remains a challenge. To identify new blood-borne tumor antigens for the purpose of establishing such assays, we have developed a novel technique called differential immunization. Using this method, we have identified PHB1 and PHB2, proteins thought to function as mitochondrial chaperones and transcriptional regulators, as antigens released from colorectal tumors in vivo. Serum from colorectal patients contains significantly higher levels of these antigens compared to serum from healthy volunteers. These data demonstrate that differential immunization is an effective new method for identifying tumor-derived antigens in serum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.