ArticleBMC gastroenterology2004
Maternal microchimerism in the livers of patients with biliary atresia.
Article in BMC gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Genetic background and biliary atresia.World journal of pediatric surgery · 2025Review
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- Immune-mediated cholangiopathies in children: the need to better understand the pathophysiology for finding the future possible treatment targets.Frontiers in immunology · 2023Review
- Selective enlargement of left lateral segment liver volume as a potential diagnostic predictor for biliary atresia.Pediatric surgery international · 2022Article
- New insights in understanding biliary atresia from the perspectives on maternal microchimerism.Frontiers in pediatrics · 2022Article
- Circulating maternal chimeric cells have an impact on the outcome of biliary atresia.Frontiers in pediatrics · 2022Article
- Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.Clinical chemistry · 2021Review
- Biliary atresia: pathology, etiology and pathogenesis.Future science OA · 2020Review
- The effect of maternal grafts in early acute cellular rejection after pediatric living-donor liver transplantation.Pediatric surgery international · 2019Article
- Recent advances in understanding biliary atresia.F1000Research · 2019Review
- Pretransplantation fetal-maternal microchimerism in pediatric liver transplantation from mother.World journal of gastroenterology · 2017Article
- Unique manifestations of biliary atresia provide new immunological insight into its etiopathogenesis.Pediatric surgery international · 2017Review
- Human Umbilical Vein Endothelial Cells foster conversion of CD4+CD25-Foxp3- T cells into CD4+Foxp3+ Regulatory T Cells via Transforming Growth Factor-β.Scientific reports · 2016Article
- Review
- Association between single nucleotide polymorphisms in the ADD3 gene and susceptibility to biliary atresia.PloS one · 2014Article
- Article
- Transfusion-associated microchimerism: the hybrid within.Transfusion medicine reviews · 2013Review
- Alterations in maternal-fetal cellular trafficking after fetal surgery.Journal of pediatric surgery · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBiliary atresia (BA) is a neonatal cholestatic disease of unknown etiology. It is the leading cause of liver transplantation in children. Many similarities exist between BA and graft versus host disease suggesting engraftment of maternal cells during gestation could result in immune responses that lead to BA. The aim of this study was to determine the presence and extent of maternal microchimerism (MM) in the livers of infants with BA.
methodsUsing fluorescent in situ hybridization (FISH), 11 male BA & 4 male neonatal hepatitis (NH) livers, which served as controls, were analyzed for X and Y-chromosomes. To further investigate MM in BA, 3 patients with BA, and their mothers, were HLA typed. Using immunohistochemical stains, the BA livers were examined for MM. Four additional BA livers underwent analysis by polymerase chain reaction (PCR) for evidence of MM.
resultsBy FISH, 8 BA and 2 NH livers were interpretable. Seven of eight BA specimens showed evidence of MM. The number of maternal cells ranged from 2-4 maternal cells per biopsy slide. Neither NH specimen showed evidence of MM. In addition, immunohistochemical stains confirmed evidence of MM. Using PCR, a range of 1-142 copies of maternal DNA per 25,000 copies of patients DNA was found.
conclusionsMaternal microchimerism is present in the livers of patients with BA and may contribute to the pathogenesis of BA.
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Registered trials
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