ArticleWorld journal of gastroenterology2004
Intestinal barrier damage caused by trauma and lipopolysaccharide.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Article
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- Dietary Histamine Impairs the Digestive Physiology Function and Muscle Quality of Hybrid Grouper (Antioxidants (Basel, Switzerland) · 2023Article
- SINPE Position Paper on the use of home parenteral nutrition in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Review
- Influence of Mushroom Polysaccharide, Nano-Copper, Copper Loaded Chitosan, and Lysozyme on Intestinal Barrier and Immunity of LPS-mediated Yellow-Feathered Chickens.Animals : an open access journal from MDPI · 2020Article
- What we already know about rhubarb: a comprehensive review.Chinese medicine · 2020Review
- Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.Molecular medicine (Cambridge, Mass.) · 2019Article
- Mechanisms by which Stress Affects the Experimental and Clinical Inflammatory Bowel Disease (IBD): Role of Brain-Gut Axis.Current neuropharmacology · 2016Review
- Biliary tract external drainage protects against intestinal barrier injury in hemorrhagic shock rats.World journal of gastroenterology · 2015Article
- Therapeutic effect of Tripterygium wilfordii Hook F multiglycosides on gut barrier dysfunction in rats with acute necrotizing pancreatitis.Experimental and therapeutic medicine · 2013Article
- The regulation of interleukin-6 implicates skeletal muscle as an integrative stress sensor and endocrine organ.Experimental physiology · 2013Review
- Evaluation of In Vitro Anti-Inflammatory Activities and Protective Effect of Fermented Preparations of Rhizoma Atractylodis Macrocephalae on Intestinal Barrier Function against Lipopolysaccharide Insult.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Vasoactive intestinal peptide promotes gut barrier function against severe acute pancreatitis.Molecular biology reports · 2012Article
- TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function.European journal of immunology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the intestinal barrier function damage induced by trauma and infection in rats.
methodsExperimental models of surgical trauma and infection were established in rats. Adult Sprague-Dawley rats were divided into 4 groups: control group (n = 8), EN group (n = 10), PN group (n = 9) and Sep group (n = 8). The rats in PN and Sep groups were made into PN models that received isonitrogenous, isocaloric and isovolumic TPN solution during the 7-d period. Rats in EN and Sep groups received laparotomy and cervical catheterization on day 1 and received lipopolysaccharide injection intraperitoneally on d 7. On the 7(th) day all the animals were gavaged with lactulose and mannitol to test the intestinal permeability. Twenty-four hours later samples were collected and examined.
resultsThe inflammatory responses became gradually aggravated from EN group to Sep group. The mucosal structure of small intestine was markedly impaired in PN and Sep groups. There was a low response in IgA level in Sep group when compared with that of EN group. Lipopolysaccharide injection also increased the nitric oxide levels in the plasma of the rats. The intestinal permeability and bacterial translocation increased significantly in Sep group compared with that of control group.
conclusionOne wk of parenteral nutrition causes an atrophy of the intestinal mucosa and results in a moderate inflammatory reaction in the rats. Endotoxemia aggravates the inflammatory responses that caused by laparotomy plus TPN, increases the production of nitric oxide in the body, and damages the intestinal barrier function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.