ArticleGenesis (New York, N.Y. : 2000)2004
Folate modulates Hox gene-controlled skeletal phenotypes.
Article in Genesis (New York, N.Y. : 2000), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.Scientific reports · 2018Article
- Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype.PloS one · 2016Article
- The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects.Clinical epigenetics · 2015Article
- Modeling anterior development in mice: diet as modulator of risk for neural tube defects.American journal of medical genetics. Part C, Seminars in medical genetics · 2013Review
- Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice.Transgenic research · 2013Article
- Genetic and epigenomic footprints of folate.Progress in molecular biology and translational science · 2012Review
- Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.Acta pharmacologica Sinica · 2010Article
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- Regulation of folate receptor 1 gene expression in the visceral endoderm.Birth defects research. Part A, Clinical and molecular teratology · 2009Article
- Article
- Degradome expression profiling in human articular cartilage.Arthritis research & therapy · 2009Article
- Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Birth defects research. Part B, Developmental and reproductive toxicology · 2007Review
- Expression of folate pathway genes in the cartilage of Hoxd4 and Hoxc8 transgenic mice.Birth defects research. Part A, Clinical and molecular teratology · 2006Article
- Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways.American journal of medical genetics. Part C, Seminars in medical genetics · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hox genes are well-known regulators of pattern formation and cell differentiation in the developing vertebrate skeleton. Although skeletal variations are not uncommon in humans few mutations in human HOX genes have been described. If such mutations are compatible with life, there may be physiological modifiers for the manifestation of Hox gene-controlled phenotypes, masking underlying mutations. Here we present evidence that the essential nutrient folate modulates genetically induced skeletal defects in Hoxd4 transgenic mice. We also show that chondrocytes require folate for growth and differentiation and that they express folate transport genes, providing evidence for a direct effect of folate on skeletal cells. To our knowledge, this is the first report of nutritional influence on Hox gene-controlled phenotypes, and implicates gene-environment interactions as important modifiers of Hox gene function. Taken together, our results demonstrate a beneficial effect of folate on skeletal development that may also be relevant to disorders and variations of the human skeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.