ArticleMolecular and cellular biology2004
Hematopoietic cell fate and the initiation of leukemic properties in primitive primary human cells are influenced by Ras activity and farnesyltransferase inhibition.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Article
- Wild-type Kras expands and exhausts hematopoietic stem cells.JCI insight · 2018Article
- From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.Journal of leukocyte biology · 2017Review
- Pleiotrophin mediates hematopoietic regeneration via activation of RAS.The Journal of clinical investigation · 2014Article
- Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells.PloS one · 2014Article
- RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiation.Leukemia · 2012Article
- A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice.Science translational medicine · 2011Article
- Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.Molecular and cellular biology · 2009Article
- Article
- Article
- Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras.Molecular and cellular biology · 2006Article
- Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells.Stem cells (Dayton, Ohio) · 2005Article
- Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro.Leukemia · 2005Article
- Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.Blood · 2005Article
- Mammary stem cells, self-renewal pathways, and carcinogenesis.Breast cancer research : BCR · 2005Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ras pathway transduces divergent signals determining normal cell fate and is frequently activated in hematopoietic malignancies, but the manner in which activation contributes to human leukemia is poorly understood. We report that a high level of activated H-Ras signaling in transduced primary human hematopoietic progenitors reduced their proliferation and enhanced monocyte/macrophage differentiation. However, the exposure of these cells to a farnesyltransferase inhibitor and establishment of a moderate level of Ras activity showed increased proliferation, an elevated frequency of primitive blast-like cells, and progenitors with enhanced self-renewal capacity. These results suggest that the amplitude of Ras pathway signaling is a determinant of myeloid cell fate and that moderate Ras activation in primitive hematopoietic cells can be an early event in leukemogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.