ArticleMolecular and cellular biology2004
Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- TheScience signaling · 2022Article
- Atypical p38 Signaling, Activation, and Implications for Disease.International journal of molecular sciences · 2021Review
- An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling.F1000Research · 2020Review
- c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice.Scientific reports · 2018Article
- Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation.Antimicrobial agents and chemotherapy · 2015Article
- Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation.Molecular and cellular biology · 2013Article
- Modulation of IL-2 expression after uptake of hepatitis C virus non-enveloped capsid-like particles: the role of p38 kinase.Cellular and molecular life sciences : CMLS · 2011Article
- Article
- Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.The Journal of experimental medicine · 2009Article
- Molecular mechanisms for adaptive tolerance and other T cell anergy models.Seminars in immunology · 2007Review
- Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.The Journal of clinical investigation · 2006Article
- Determinants that control the specific interactions between TAB1 and p38alpha.Molecular and cellular biology · 2006Article
- High Mda-7 expression promotes malignant cell survival and p38 MAP kinase activation in chronic lymphocytic leukemia.Leukemia · 2006Article
- The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells.Arthritis research & therapy · 2006Review
Corrections and comments
- Correction · 2005-10-01Concerns/Issues about Results and/or Conclusions · Error in Analyses · Error in Results and/or Conclusions ·
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In anergic T cells, T-cell receptor (TCR)-mediated responses are functionally inactivated by negative regulatory signals whose mechanisms are poorly understood. Here, we show that CD4(+) T cells anergized in vivo by superantigen Mls-1(a) express a scaffolding protein, transforming growth factor beta-activated protein kinase 1-binding protein 1 (TAB1), that negatively regulates TCR signaling through the activation of mitogen-activated protein kinase p38 alpha. TAB1 was not expressed in naive and activated CD4(+) T cells. Inhibition of p38 activity in anergic T cells by a chemical inhibitor resulted in the recovery of interleukin 2 (IL-2) and the inhibition of IL-10 secretion. T-cell hybridoma 2B4 cells transduced with TAB1-containing retrovirus (TAB1-2B4 cells) showed activated p38 alpha, inhibited extracellular signal-regulated kinase (ERK) activity, culminating in reduced IL-2 levels and increased IL-10 production. The use of a p38 inhibitor or cotransfection of a dominant-negative form of p38 in TAB1-2B4 cells resulted in the recovery of ERK activity and IL-2 production. These results imply that TAB1-mediated activation of p38 alpha in anergic T cells regulates the maintenance of T-cell unresponsiveness both by inhibiting IL-2 production and by promoting IL-10 production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.