ArticleThe Biochemical journal2004
Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- DUSP family phosphatases in cell signaling, inflammation, and chronic diseases.Journal of biomedical science · 2026Review
- Targeting dual-specificity phosphatase 23 to overcome chemoresistance and stem cell-like behavior in non-small cell lung cancer cells.Scientific reports · 2025Article
- Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies.Communications biology · 2025Article
- Dual-specificity phosphatase 23 functions as a promising prognostic biomarker in non-small cell lung cancer.Genes & genomics · 2025Article
- A Review of DUSP26: Structure, Regulation and Relevance in Human Disease.International journal of molecular sciences · 2021Review
- Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway.International journal of molecular sciences · 2019Review
- Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation.International journal of molecular sciences · 2019Review
- Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis.BMC systems biology · 2018Article
- Identification of PTPN1 as a novel negative regulator of the JNK MAPK pathway using a synthetic screening for pathway-specific phosphatases.Scientific reports · 2017Article
- DUSP23 is over-expressed and linked to the expression of DNMTs in CD4Clinical and experimental immunology · 2017Article
- Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28.PloS one · 2017Article
- Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway.PloS one · 2016Article
- New functional aspects of the atypical protein tyrosine phosphatase VHZ.Biochemistry · 2013Article
- New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening.Biochemistry · 2012Article
- Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum.Molecular and cellular biochemistry · 2012Article
- DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.Molecular and cellular biochemistry · 2011Article
- Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation.Nucleic acids research · 2011Article
- Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A.Cellular and molecular life sciences : CMLS · 2010Article
- VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers.Molecular cancer · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a mouse cDNA for a novel dual-specificity phosphatase designated LDP-3 (low-molecular-mass dual-specificity phosphatase 3). The 450 bp open reading frame encodes a protein of 150 amino acids with a predicted molecular mass of 16 kDa. Northern blot and reverse transcription-PCR analyses show that LDP-3 transcripts are expressed in almost all mouse tissues examined. In vitro analyses using several substrates and inhibitors indicate that LDP-3 possesses intrinsic dual-specificity phosphatase activity. When expressed in mammalian cells, LDP-3 protein is localized mainly to the apical submembrane area. Forced expression of LDP-3 does not alter activation of ERK (extracellular-signal-regulated kinase), but rather enhances activation of JNK (c-Jun N-terminal kinase) and p38 and their respective upstream kinases MKK4 (mitogen-activated protein kinase kinase 4) and MKK6 in cells treated with 0.4 M sorbitol. By screening with a variety of stimuli, we found that LDP-3 specifically enhances the osmotic stress-induced activation of JNK and p38.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.