ArticleBritish journal of cancer2004
High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma.
Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- A cisplatin plus pirarubicin-based JPLT2 chemotherapy for hepatoblastoma: experience and future of the Japanese Study Group for Pediatric Liver Tumor (JPLT).Pediatric surgery international · 2013Trial
- PI3K/Akt/mTOR pathway expression profiling reveals age- and subtype-specific molecular heterogeneity in the Nigerian breast cancer landscape.Frontiers in oncology · 2026Article
- Hepatoblastoma.Nature reviews. Disease primers · 2025Review
- Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes.Biomedicines · 2021Review
- Telomere Maintenance in Pediatric Cancer.International journal of molecular sciences · 2019Review
- Telomerase and Telomeres in Endometrial Cancer.Frontiers in oncology · 2019Review
- Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.International journal of molecular sciences · 2017Review
- Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis.American journal of translational research · 2016Article
- Telomerase activity in peripheral blood mononuclear cells as a universal scale for quantitative measurement of telomerase activation on the example of liver diseases.Doklady. Biochemistry and biophysics · 2015Article
- Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas.Journal of neuro-oncology · 2014Article
- G-quadruplexes as potential therapeutic targets for embryonal tumors.Molecules (Basel, Switzerland) · 2013Review
- Primary malignant liver tumors in children.Indian journal of pediatrics · 2012Review
- Telomerase reverse transcriptase catalytic subunit expression and proliferation index in Wilms tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Prognostic value of hedgehog signal component expressions in hepatoblastoma patients.European journal of medical research · 2010Article
- Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Article
- Possibility of selection of chondrogenic progenitor cells by telomere length in FGF-2-expanded mesenchymal stromal cells.Cell proliferation · 2006Article
- Telomerase detection in the diagnosis and prognosis of cancer.Cytotechnology · 2004Article
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13 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human telomerase. To evaluate whether the levels of hTERT mRNA provides a molecular marker of hepatoblastoma malignancy, we examined hTERT mRNA expression levels in the primary hepatoblastoma tissues by fluorescent RT-PCR using LightCycler technology and followed up the clinical outcomes in 63 patients listed in the Japanese Study Group of Pediatric Liver Tumor between 1991 and 2002. The hTERT mRNA expression was detected in 61 (96.8%) specimens and their expression levels ranged between 0.1/1000 and 745.1/1000 copies of PBGD gene that was used as an internal control. Among these cases, frozen 39 tumour samples and 14 adjacent noncancerous liver tissues were analysed for semiquantitative telomerase assay. In the 39 tumour samples, the levels of telomerase activity ranged between 0.11 and 2709 TPG and 12 (30.7%) had high telomerase activity (>100 TPG), whereas only nine of 14 noncancerous liver tissue samples showed telomerase activity which was less than 1.0 TPG. The levels of telomerase activity were significantly correlated with the levels of hTERT mRNA expression (P<0.001). The frequency of high hTERT mRNA expression and/or high telomerase activity did not significantly associate with the clinicopathological factors except for stage of disease. The prognosis of the patients with high hTERT mRNA expression was significantly worse than that of others (P<0.01), as was the patients with high telomerase activity (P<0.01). Multivariate analysis indicated that high levels of hTERT mRNA expression as well as telomerase activity are independent prognosis-predicting factors in patients with hepatoblastoma.
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