ArticleProceedings of the National Academy of Sciences of the United States of America2004
Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Perioperative comparison between robotic-assisted and freehand total knee arthroplasty : A quasi-randomized controlled trial.Orthopadie (Heidelberg, Germany) · 2026Trial
- ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts.Frontiers in cell and developmental biology · 2022Article
- Comprehensive History ofGenes · 2020Review
- Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.Insect biochemistry and molecular biology · 2020Article
- First detection of aEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri.Toxins · 2017Article
- Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function.Nucleic acids research · 2016Article
- Is there more than one way to skin a newt? Convergent toxin resistance in snakes is not due to a common genetic mechanism.Heredity · 2016Article
- A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.Nature communications · 2014Article
- Molecular biology of insect sodium channels and pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.Neuroscience · 2014Article
- Voltage-Gated Sodium Channels as Insecticide Targets.Advances in insect physiology · 2014Article
- A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus.Scientific reports · 2012Article
- Molecular characterization and functional expression of the DSC1 channel.Insect biochemistry and molecular biology · 2011Article
- RNA editing in P transposable element read-through transcripts in Drosophila melanogaster.Genetica · 2010Article
- Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels.The Journal of biological chemistry · 2009Article
- Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current.Journal of neurophysiology · 2009Article
- The evolutionary origins of beneficial alleles during the repeated adaptation of garter snakes to deadly prey.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides.Toxicology and applied pharmacology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistent tetrodotoxin (TTX)-sensitive sodium current, detected in neurons of many regions of mammalian brains, is associated with many essential neuronal activities, including boosting of excitatory synaptic inputs, acceleration of firing rates, and promotion of oscillatory neuronal activities. However, the origin and molecular basis of the persistent current have remained controversial for decades. Here, we provide direct evidence that U-to-C RNA editing of an insect sodium channel transcript generates a sodium channel with a persistent current. We detected a persistent TTX-sensitive current in a splice variant of the cockroach sodium channel gene BgNa(v) (formerly para(CSMA)). Site-directed mutagenesis experiments revealed that an F-to-S change at the C-terminal domain of this variant was responsible for the persistent current. We demonstrated that this F-to-S change was the result of a U-to-C RNA editing event, which also occurred in the Drosophila para sodium channel transcript. Our work provides direct support for the hypothesis that posttranscriptional modification of a conventional transient sodium channel produces a persistent TTX-sensitive sodium channel.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.