ArticleJournal of virology2004
Evidence that rabies virus forms different kinds of fusion machines with different pH thresholds for fusion.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7.Nature communications · 2024Article
- Cell type-specific delivery by modular envelope design.Nature communications · 2023Article
- Production and Use of Gesicles for Nucleic Acid Delivery.Molecular biotechnology · 2022Article
- The Serine/Threonine Kinase AP2-Associated Kinase 1 Plays an Important Role in Rabies Virus Entry.Viruses · 2019Article
- Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses.Journal of virology · 2016Article
- Real-time Imaging of Rabies Virus Entry into Living Vero cells.Scientific reports · 2015Article
- Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.Journal of virology · 2013Article
- The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.Physiological reviews · 2013Review
- Molecular and cellular aspects of rhabdovirus entry.Viruses · 2012Article
- A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion.Journal of virology · 2011Article
- Distinct structural rearrangements of the VSV glycoprotein drive membrane fusion.The Journal of cell biology · 2010Article
- A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins.Nature reviews. Microbiology · 2010Review
- Avoiding the void: cell-to-cell spread of human viruses.Nature reviews. Microbiology · 2008Review
- Double-labeled rabies virus: live tracking of enveloped virus transport.Journal of virology · 2008Article
- An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations.Journal of molecular biology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusion of rabies virus with membranes is triggered at a low pH and is mediated by a viral glycoprotein (G). Fusion of rabies virus with liposomes was monitored by using a lipid mixing assay based on fluorescence resonance energy transfer. Fusion was detected below pH 6.4, and its extent increased with H(+) concentrations to be maximal around pH 6.15. The origin of the partial fusion activity of rabies virus under suboptimal pH conditions (i.e., between pH 6.15 and 6.4) was investigated. We demonstrate unambiguously that fusion at a suboptimal pH is distinct from the phenomenon of low-pH-induced inactivation and that it is not due to heterogeneity of the virus population. We also show that viruses that do not fuse under suboptimal pH conditions are indeed bound to the target liposomes and that the fusion complexes they have formed are blocked at an early stage of the fusion pathway. Our conclusion is that along the fusion reaction, different kinds of fusion machines with different pH thresholds for fusion can be formed. Possible explanations of this difference of pH sensitivity are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.