ArticleJournal of clinical pathology2004
Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease?
Article in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Guideline
- A tip-predominant distribution of villous intraepithelial lymphocytes is not specific to celiac disease in children with Marsh I lesions.American journal of clinical pathology · 2024Article
- Potential pitfalls in reporting non-neoplastic gastrointestinal mucosal biopsies.Histology and histopathology · 2023Review
- Immunohistochemical analysis of intestinal biopsies in individuals with celiac disease.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Minimal Lesions of the Small Intestinal Mucosa: More than Morphology.Digestive diseases and sciences · 2020Review
- Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder.Frontiers in immunology · 2020Review
- Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.Nature communications · 2019Article
- Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach.Virchows Archiv : an international journal of pathology · 2018Article
- Article
- A Commensal Bifidobacterium longum Strain Prevents Gluten-Related Immunopathology in Mice through Expression of a Serine Protease Inhibitor.Applied and environmental microbiology · 2017Article
- Morphologic Spectrum of Duodenal Biopsies in Malabsorption: A Study from Southern India.Journal of clinical and diagnostic research : JCDR · 2017Article
- Evolutionary Developments in Interpreting the Gluten-Induced Mucosal Celiac Lesion: An Archimedian Heuristic.Nutrients · 2017Review
- Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease).World journal of gastroenterology · 2017Review
- T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity.Gastroenterology research and practice · 2017Article
- Intraepithelial lymphocytes subsets in different forms of celiac disease.Auto- immunity highlights · 2016Article
- Outcomes of Seropositive Patients With Marsh 1 Histology in Clinical Practice.Journal of clinical gastroenterology · 2016Article
- Novel role of the serine protease inhibitor elafin in gluten-related disorders.The American journal of gastroenterology · 2014Article
- Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen.PloS one · 2014Article
- Celiac disease: clinch the diagnosis when it is just around the corner.Digestive diseases and sciences · 2013Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe counting of intraepithelial lymphocytes (IELs) in the villous tips of architecturally normal small bowel biopsy specimens was proposed as a method to measure mucosal infiltration in gluten sensitive patients.
aimsTo apply this straightforward method in duodenal biopsy specimens from patients affected by potential coeliac disease (PCD) to verify whether it can discriminate these patients from controls.
methodsParaffin wax embedded duodenal sections from 11 patients affected by PCD were stained with an antihuman CD3 antibody. Sections from 19 patients affected by treated coeliac disease (TCD) and 17 patients in whom coeliac disease was excluded were stained with the same antibody to serve as controls. The slides were examined blindly. IELs/20 enterocytes in five randomly chosen villous tips were counted. Patients affected by PCD were all on a gluten containing diet. They had an architecturally normal duodenal mucosa and were positive for endomysial antibody. Both TCD and non-coeliac controls were negative for endomysial antibody.
resultsThe mean villous tip IEL scores were 4.6 (SD, 1.5; range, 1.4-7.8) in non-coeliac controls, 7.9 (SD, 4.0; range, 2.0-18.6) in TCD, and 9.2 (SD, 4.7; range, 5.8-21.8) in patients with PCD. The difference between PCD and non-coeliac controls was significant.
conclusionsThis is a very simple and sufficiently reliable method to count IELs. In patients with an architecturally normal duodenal mucosa, the IEL count in villous tips helps to distinguish between patients with PCD and non-coeliac controls.
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