ArticleGenetics2004
Nucleotide variation in the Egfr locus of Drosophila melanogaster.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Two Drosophilids exhibit distinct EGF pathway patterns in oogenesis.Development genes and evolution · 2018Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
- Recombination modulates how selection affects linked sites in Drosophila.PLoS biology · 2012Article
- Genomic differentiation between temperate and tropical Australian populations of Drosophila melanogaster.Genetics · 2011Article
- Estimation of fine-scale recombination intensity variation in the white-echinus interval of D. melanogaster.Journal of molecular evolution · 2009Article
- Recombinational landscape and population genomics of Caenorhabditis elegans.PLoS genetics · 2009Article
- Genetic variation for cardiac dysfunction in Drosophila.PloS one · 2007Article
- How repeatable are associations between polymorphisms in achaete-scute and bristle number variation in Drosophila?Genetics · 2007Article
- Mixture modeling of transcript abundance classes in natural populations.Genome biology · 2007Article
- Fine-scale crossover rate heterogeneity in Drosophila pseudoobscura.Journal of molecular evolution · 2007Article
- Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology.BMC genetics · 2005Article
- Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster.Genetics · 2005Article
- Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate.Genetics · 2004Article
- Association between nucleotide variation in Egfr and wing shape in Drosophila melanogaster.Genetics · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Epidermal growth factor receptor is an essential gene with diverse pleiotropic roles in development throughout the animal kingdom. Analysis of sequence diversity in 10.9 kb covering the complete coding region and 6.4 kb of potential regulatory regions in a sample of 250 alleles from three populations of Drosophila melanogaster suggests that the intensity of different population genetic forces varies along the locus. A total of 238 independent common SNPs and 20 indel polymorphisms were detected, with just six common replacements affecting >1475 amino acids, four of which are in the short alternate first exon. Sequence diversity is lowest in a 2-kb portion of intron 2, which is also highly conserved in comparison with D. simulans and D. pseudoobscura. Linkage disequilibrium decays to background levels within 500 bp of most sites, so haplotypes are generally restricted to up to 5 polymorphisms. The two North American samples from North Carolina and California have diverged in allele frequency at a handful of individual SNPs, but a Kenyan sample is both more divergent and more polymorphic. The effect of sample size on inference of the roles of population structure, uneven recombination, and weak selection in patterning nucleotide variation in the locus is discussed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.