ArticleGenetics2004
Association between nucleotide variation in Egfr and wing shape in Drosophila melanogaster.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Extensive genetic differentiation between recently evolved sympatric Arctic charr morphs.Ecology and evolution · 2019Article
- Article
- The sex-limited effects of mutations in the EGFR and TGF-β signaling pathways on shape and size sexual dimorphism and allometry in the Drosophila wing.Development genes and evolution · 2016Article
- Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster.PloS one · 2016Article
- The developmental transcriptome of contrasting Arctic charr (F1000Research · 2015Article
- Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.Genetics · 2014Article
- Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.PloS one · 2014Article
- Abundance and distribution of transposable elements in two Drosophila QTL mapping resources.Molecular biology and evolution · 2013Article
- Differentiation at the MHCIIα and Cath2 loci in sympatric Salvelinus alpinus resource morphs in Lake Thingvallavatn.PloS one · 2013Article
- A test for selection employing quantitative trait locus and mutation accumulation data.Genetics · 2012Article
- The QTN program and the alleles that matter for evolution: all that's gold does not glitter.Evolution; international journal of organic evolution · 2012Article
- Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation.BMC developmental biology · 2011Article
- Article
- A strong quantitative trait locus for wing length on chromosome 2 in a wild population of great reed warblers.Proceedings. Biological sciences · 2010Article
- Mutations and quantitative genetic variation: lessons from Drosophila.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The genetics of quantitative traits: challenges and prospects.Nature reviews. Genetics · 2009Review
- Evolution of sexual dimorphism of wing shape in the Drosophila melanogaster subgroup.BMC evolutionary biology · 2009Article
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
- Connecting QTLS to the g-matrix of evolutionary quantitative genetics.Evolution; international journal of organic evolution · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As part of an effort to dissect quantitative trait locus effects to the nucleotide level, association was assessed between 238 single-nucleotide and 20 indel polymorphisms spread over 11 kb of the Drosophila melanogaster Egfr locus and nine relative warp measures of wing shape. One SNP in a conserved potential regulatory site for a GAGA factor in the promoter of alternate first exon 2 approaches conservative experiment-wise significance (P < 0.00003) in the sample of 207 lines for association with the location of the crossveins in the central region of the wing. Several other sites indicate marginal association with one or more other aspects of shape. No strong effects of sex or population of origin were detected with measures of shape, but two different sites were strongly associated with overall wing size in interaction with these fixed factors. Whole-gene sequencing in very large samples, rather than selective genotyping, would appear to be the only strategy likely to be successful for detecting subtle associations in species with high polymorphism and little haplotype structure. However, these features severely limit the ability of linkage disequilibrium mapping in Drosophila to resolve quantitative effects to single nucleotides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.