ArticleGenetics2004
Alleles of the hotspot cog are codominant in effect on recombination in the his-3 region of Neurospora.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- High-resolution mapping of the recombination landscape of the phytopathogen Fusarium graminearum suggests two-speed genome evolution.Molecular plant pathology · 2018Article
- Meiotic Recombination in Neurospora crassa Proceeds by Two Pathways with Extensive Holliday Junction Migration.PloS one · 2016Article
- Use of fluorescent protein to analyse recombination at three loci in Neurospora crassa.Fungal genetics and biology : FG & B · 2012Article
- A crossover hotspot near his-3 in Neurospora crassa is a preferential recombination termination site.Molecular genetics and genomics : MGG · 2012Article
- Article
- Rapid genetic mapping in Neurospora crassa.Fungal genetics and biology : FG & B · 2007Article
- Chromosome pairing and meiotic recombination in Neurospora crassa spo11 mutants.Current genetics · 2006Article
- Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identification.Genetics · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are two naturally occurring functional alleles of the recombination hotspot cog, which is located 3.5 kb from the his-3 locus of Neurospora crassa. The presence of the cog+ allele in a cross significantly increases recombination in the his-3 region compared to a cross homozygous for the cog allele. Data obtained shortly after discovery of cog+ suggested that it was fully dominant to cog. However, a dominant cog+ conflicts with observations of hotspots in Saccharomyces cerevisiae and Schizosaccharomyces pombe, in which recombination is initiated independently of homolog interactions, and suggests recombination mechanisms may differ in Neurospora and yeast. We present evidence that cog alleles are codominant in effect on both allelic recombination in his-3 and crossing over between loci flanking his-3. In addition, we show that genetic background variation has at least a twofold effect on allelic recombination. We speculate that variation in genetic background, together with the complexities of recombination in crosses bearing close mutant alleles, accounts for the previous conclusion that cog+ is dominant to cog.
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