ReviewNeuro-oncology2004
Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature.
Review in Neuro-oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for the assessment and acceptance of potential brain-dead organ donors.Revista Brasileira de terapia intensiva · 2016Guideline
- A case report about extracranial skeletal metastases in pediatric diffuse midline glioma, H3 K27-altered.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Donors With Previous Malignancy: When Is It Safe to Proceed With Organ Transplantation?Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Potential organ donors with primary brain tumours: missed opportunities for donation and transplantation identified in Australian cohort study 2010-2015.ANZ journal of surgery · 2022Article
- Mechanoregulation of Metastasis beyond the Matrix.Cancer research · 2022Article
- Glioblastoma: an organ-confined disease?Translational cancer research · 2022Article
- Risk factors of extraneural spreading in astrocytomas and oligodendrogliomas in donors with gliomas: A systematic review.World journal of transplantation · 2022Article
- A Rare Case of Metastatic Glioblastoma Diagnosed by Endobronchial Ultrasound-Transbronchial Needle Aspiration.Case reports in pulmonology · 2022Article
- Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant.Life science alliance · 2021Article
- Rapid screening for safety of donation from donors with central nervous system malignancies.Medicine · 2020Review
- Metabolic reprogramming and cancer progression.Science (New York, N.Y.) · 2020Review
- Article
- Risk factors associated with post-kidney transplant malignancies: an article from the Cancer-Kidney International Network.Clinical kidney journal · 2018Article
- A Rare Case of Glioblastoma Multiforme with Osseous Metastases.Case reports in oncological medicine · 2017Article
- Extracranial metastasis of gliobastoma: Three illustrative cases and current review of the molecular pathology and management strategies.Molecular and clinical oncology · 2015Article
- Circulating glioma biomarkers.Neuro-oncology · 2015Review
- Cancer Metastases: Early Dissemination and Late Recurrences.Cancer growth and metastasis · 2015Review
- Emerging treatment strategies for glioblastoma multiforme.EMBO molecular medicine · 2014Review
- Extracranial glioblastoma in transplant recipients.Journal of cancer research and clinical oncology · 2014Article
- Emerging methods for disease monitoring in malignant gliomas.CNS oncology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.