ArticleJournal of virology1992
Dissociation of unintegrated viral DNA accumulation from single-cell lysis induced by human immunodeficiency virus type 1.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Episomal HIV-1 DNA and its relationship to other markers of HIV-1 persistence.Retrovirology · 2018Review
- The role of unintegrated DNA in HIV infection.Retrovirology · 2011Review
- Article
- Avian sarcoma and leukosis virus cytopathic effect in the absence of TVB death domain signaling.Journal of virology · 2005Article
- HIV-1 gene expression: lessons from provirus and non-integrated DNA.Retrovirology · 2004Review
- Viral and cellular dynamics in HIV disease.Current HIV/AIDS reports · 2004Review
- Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants.Journal of virology · 2004Article
- Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.Journal of virology · 2002Article
- Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous.Journal of virology · 2002Article
- Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylation.Journal of virology · 2001Article
- Mink cell focus-forming murine leukemia virus killing of mink cells involves apoptosis and superinfection.Journal of virology · 2001Article
- Viral and Cellular Dynamics in HIV Disease.Current infectious disease reports · 2001Article
- TVB receptors for cytopathic and noncytopathic subgroups of avian leukosis viruses are functional death receptors.Journal of virology · 2000Article
- Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin.Journal of virology · 1998Article
- N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with impaired gp120 shedding and gp41 exposure.Journal of virology · 1996Article
- Interference to human immunodeficiency virus type 1 infection in the absence of downmodulation of the principal virus receptor, CD4.Journal of virology · 1996Article
- Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1.Journal of virology · 1996Article
- Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1.Journal of virology · 1995Article
- Role of apoptosis in HIV disease pathogenesis.Journal of clinical immunology · 1995Review
- Spontaneous reversion of human immunodeficiency virus type 1 neutralization-resistant variant HXB2thr582: in vitro selection against cytopathicity highlights gp120-gp41 interactive regions.Journal of virology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Acute cytopathic retroviral infections are accompanied by the accumulation, due to superinfection, of large amounts of unintegrated viral DNA in the cells. The cytopathic effects of human immunodeficiency virus type 1 (HIV-1) infection are specific for cells that express the CD4 viral receptor and consist of syncytium formation and single-cell lysis. Here we investigated the relationship between superinfection and single-cell lysis by HIV-1. Antiviral agents were added to C8166 or Jurkat lymphocytes after HIV-1 infection had occurred. Treatment with azidothymidine or a neutralizing anti-gp120 monoclonal antibody reduced or eliminated, respectively, the formation of unintegrated viral DNA but did not inhibit single-cell killing. Furthermore, in the infected Jurkat cells, the levels of unintegrated viral DNA peaked several days before significant single-cell lysis was observed. Essentially complete superinfection resistance was established before the occurrence of single-cell killing. These results demonstrate that single-cell lysis by HIV-1 can be dissociated from superinfection and unintegrated viral DNA accumulation. These results also indicate that single-cell killing may involve envelope glycoprotein-receptor interactions not accessible to the exterior of the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.