ArticleThe Journal of cell biology2004
Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 448 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
448 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- PAX7, a Key for Myogenesis Modulation in Muscular Dystrophies through Multiple Signaling Pathways: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Pooled it
- Hypoxic Signaling in Skeletal Muscle Maintenance and Regeneration: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Skeletal muscle-derived cell implantation for the treatment of sphincter-related faecal incontinence.Stem cell research & therapy · 2018Trial
- MuSC cultivation for cultured meat production: recent advances, current limitations, and future directions.Food science of animal resources · 2026Review
- L-carnosine alleviates wooden breast myopathy in broilers fed oxidized soybean oil: Focus on antioxidant defense, calcium homeostasis, and satellite cell function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Phase-transition failure in aged skeletal muscle regeneration.Biogerontology · 2026Review
- State-Dependent FGF Signaling in Satellite Cell-Mediated Skeletal Muscle Regeneration and Pathological Remodeling.Biomolecules · 2026Review
- TRF2 couples muscle stem cell identity to regenerative repair.Science advances · 2026Article
- Non-apoptotic role of caspase enzymes in satellite cells from human skeletal muscle.Biogerontology · 2026Article
- The Injection of miR-1/133 Antagonist Notably Accelerated the Healing Process of Exercise-Induced Skeletal Muscle Injury.Physiological research · 2026Article
- Slow and fast locomotor muscle adaptations to sustained intermittent hypoxaemia.The journal of physiological sciences : JPS · 2026Article
- Myostatin Inhibitory D‑Peptides Induce Skeletal Muscle Hypertrophy along with Alteration of Bioactive Sphingolipid Metabolism.ACS pharmacology & translational science · 2026Article
- Changes in gene expression at the early stages of barramundi (Lates calcarifer) muscle cell line development.Molecular biology reports · 2026Article
- Type 2 deiodinase-dependent surge in thyroid hormone controls muscle stem cell quiescence and self-renewal.The Journal of clinical investigation · 2026Article
- Renalase knockdown inhibits proliferation of mouse satellite cells.Molecular biology reports · 2026Article
- Pharmacological Inhibition of N-terminal methyltransferase 1 promotes myogenic differentiation and muscle regeneration in a mouse model of Duchenne muscular dystrophy.Stem cell research & therapy · 2026Article
- C-peptide promotes myogenic differentiation in vitro and low serum levels are associated with sarcopenia in adults and the elderly.Journal of translational medicine · 2026Article
- MG53 in Early Skeletal Muscle Stem Cell Activation: Implications for Aged Muscle Regeneration.Cells · 2026Review
- Grb2/Sos1 signaling regulates the number of reserve cells in C2C12 cell culture.In vitro cellular & developmental biology. Animal · 2026Article
388 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Growth, repair, and regeneration of adult skeletal muscle depends on the persistence of satellite cells: muscle stem cells resident beneath the basal lamina that surrounds each myofiber. However, how the satellite cell compartment is maintained is unclear. Here, we use cultured myofibers to model muscle regeneration and show that satellite cells adopt divergent fates. Quiescent satellite cells are synchronously activated to coexpress the transcription factors Pax7 and MyoD. Most then proliferate, down-regulate Pax7, and differentiate. In contrast, other proliferating cells maintain Pax7 but lose MyoD and withdraw from immediate differentiation. These cells are typically located in clusters, together with Pax7-ve progeny destined for differentiation. Some of the Pax7+ve/MyoD-ve cells then leave the cell cycle, thus regaining the quiescent satellite cell phenotype. Significantly, noncycling cells contained within a cluster can be stimulated to proliferate again. These observations suggest that satellite cells either differentiate or switch from terminal myogenesis to maintain the satellite cell pool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.