ArticleInvestigative ophthalmology & visual science2004
Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters.
Article in Investigative ophthalmology & visual science, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Differential activity of transcription factors and neuronal effectors during the development of pikeperch brain.Biology open · 2025Article
- Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study.World journal of diabetes · 2025Article
- Article
- Krüppel-like factors family in health and disease.MedComm · 2024Review
- Glucose uptake by GLUT1 in photoreceptors is essential for outer segment renewal and rod photoreceptor survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Establishment and Analysis of a Combined Diagnostic Model of Alzheimer's Disease With Random Forest and Artificial Neural Network.Frontiers in aging neuroscience · 2022Article
- Krüppel-Like Factor 15 ModulatesFrontiers in cell and developmental biology · 2021Article
- Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.The Biochemical journal · 2019Article
- A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet.PloS one · 2019Article
- Targeting and silencing of rhodopsin by ectopic expression of the transcription factor KLF15.JCI insight · 2017Article
- The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry.Molecular and cellular biology · 2013Article
- Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications.PloS one · 2012Article
- The Krüppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy.The Journal of biological chemistry · 2011Article
- Multiple transcription factor families regulate axon growth and regeneration.Developmental neurobiology · 2011Review
- Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration.Molecular and cellular neurosciences · 2011Review
- Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.BMC biotechnology · 2011Article
- Multimodal regulation of E2F1 gene expression by progestins.Molecular and cellular biology · 2010Article
- Regulation of photoreceptor gene expression by the retinal homeobox (Rx) gene product.Developmental biology · 2010Article
- Sp1 and KLF15 regulate basal transcription of the human LRP5 gene.BMC genetics · 2010Article
- Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo identify novel transcriptional regulators of rhodopsin expression as a model for understanding photoreceptor-specific gene regulation.
methodsA bovine retinal cDNA library was screened in a yeast one-hybrid assay, with a 29-bp bovine rhodopsin promoter fragment as bait. Expression studies used RT-PCR and beta-galactosidase (LacZ) histochemistry of retinas from transgenic mice heterozygous for a targeted LacZ replacement of KLF15. Promoter transactivation assays measured luciferase expression in HEK293 cells transiently transfected with bovine rhodopsin or IRBP promoter-reporter constructs and expression constructs containing cDNAs for full or truncated KLF15, Crx (cone rod homeobox), and/or Nrl (neural retina leucine zipper). Data were analyzed with general linear models.
resultsThe zinc-finger transcription factor KLF15 was identified as a rhodopsin-promoter-binding protein in a yeast one-hybrid screen. Expression was detected by RT-PCR in multiple tissues, including the retina, where KLF15-LacZ was observed in the inner nuclear layer, ganglion cell layer, and pigmented epithelial cells, but not in photoreceptors. KLF15 repressed transactivation of rhodopsin and IRBP promoters alone and in combination with the transcriptional activators Crx and/or Nrl. Repressor activity required both a 198-amino-acid element in the N-terminal domain and the C-terminal zinc finger DNA-binding domains.
conclusionsThe zinc finger containing transcription factor KLF15 is a transcriptional repressor of the rhodopsin and IRBP promoters in vitro and, in the retina, is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.